Class of enzymes
3′,5′-cyclic-GMP phosphodiesterase |
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Identifiers |
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EC no. | 3.1.4.35 |
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CAS no. | 9068-52-4 |
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Databases |
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IntEnz | IntEnz view |
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BRENDA | BRENDA entry |
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ExPASy | NiceZyme view |
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KEGG | KEGG entry |
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MetaCyc | metabolic pathway |
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PRIAM | profile |
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PDB structures | RCSB PDB PDBe PDBsum |
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Gene Ontology | AmiGO / QuickGO |
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Search |
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PMC | articles |
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PubMed | articles |
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NCBI | proteins |
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The enzyme 3′,5′-cyclic-GMP phosphodiesterase (EC 3.1.4.35) catalyzes the reaction
- guanosine 3′,5′-cyclic phosphate + H2O guanosine 5′-phosphate
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is 3′,5′-cyclic-GMP 5'-nucleotidohydrolase. Other names in common use include guanosine cyclic 3',5'-phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3′,5′-GMP phosphodiesterase, cyclic guanosine 3′,5′-monophosphate phosphodiesterase, cyclic guanosine 3′,5′-phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3′,5′-phosphate phosphodiesterase.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1MC0, 2CHM, 2H40, 2H42, and 2H44.
References
- Marks F, Raab I (1974). "The second messenger system of mouse epidermis. IV. Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368–377. doi:10.1016/0005-2744(74)90180-6.
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Portal:- Biology
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