Protein-coding gene in the species Homo sapiens
ATP1B3 |
---|
|
Identifiers |
---|
Aliases | ATP1B3, ATPB-3, CD298, ATPase Na+/K+ transporting subunit beta 3 |
---|
External IDs | OMIM: 601867; MGI: 107788; HomoloGene: 37510; GeneCards: ATP1B3; OMA:ATP1B3 - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 3 (human)[1] |
---|
| Band | 3q23 | Start | 141,876,124 bp[1] |
---|
End | 141,926,549 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 9 (mouse)[2] |
---|
| Band | 9 E3.3|9 50.31 cM | Start | 96,214,708 bp[2] |
---|
End | 96,246,495 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - sperm
- skin of thigh
- skin of hip
- gingival epithelium
- mucosa of colon
- mucosa of pharynx
- stromal cell of endometrium
- vulva
- mucosa of sigmoid colon
- mucosa of transverse colon
|
| Top expressed in | - sciatic nerve
- epithelium of lens
- seminiferous tubule
- choroid plexus of fourth ventricle
- corneal stroma
- gastrula
- molar
- utricle
- skin of external ear
- superior surface of tongue
|
| More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | - ATPase binding
- P-type sodium:potassium-exchanging transporter activity
- ATPase activator activity
| Cellular component | - cytoplasm
- integral component of membrane
- membrane
- melanosome
- plasma membrane
- sodium:potassium-exchanging ATPase complex
- caveola
- extracellular exosome
| Biological process | - regulation of cardiac conduction
- positive regulation of ATP-dependent activity
- positive regulation of sodium ion export across plasma membrane
- sodium ion transport
- cellular sodium ion homeostasis
- sodium ion export across plasma membrane
- metal ion transport
- positive regulation of potassium ion import across plasma membrane
- protein stabilization
- ion transport
- cellular potassium ion homeostasis
- potassium ion transport
- membrane repolarization
- ion transmembrane transport
- protein localization to plasma membrane
- leukocyte migration
- positive regulation of potassium ion transmembrane transporter activity
- establishment or maintenance of transmembrane electrochemical gradient
- transport
- potassium ion import across plasma membrane
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
NM_007502 NM_001357212 NM_001357213 |
|
---|
RefSeq (protein) | | |
---|
NP_031528 NP_001344141 NP_001344142 |
|
---|
Location (UCSC) | Chr 3: 141.88 – 141.93 Mb | Chr 9: 96.21 – 96.25 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|
Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene.[5][6][7] ATP1B3 has also been designated as CD298 (cluster of differentiation 298).
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000069849 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032412 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Malik N, Canfield VA, Beckers MC, Gros P, Levenson R (Nov 1996). "Identification of the mammalian Na,K-ATPase 3 subunit". J Biol Chem. 271 (37): 22754–8. doi:10.1074/jbc.271.37.22754. PMID 8798450.
- ^ Malik N, Canfield V, Sanchez-Watts G, Watts AG, Scherer S, Beatty BG, Gros P, Levenson R (Mar 1998). "Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene". Mamm Genome. 9 (2): 136–43. doi:10.1007/s003359900704. PMID 9457675. S2CID 31228553.
- ^ a b "Entrez Gene: ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide".
Further reading
- Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na,K-ATPase". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 38: 37–89. doi:10.1016/S0079-6603(08)60708-4. ISBN 978-0-12-540038-1. PMID 2158121.
- Jørgensen PL (1982). "Mechanism of the Na+, K+ pump. Protein structure and conformations of the pure (Na+ +K+)-ATPase". Biochim. Biophys. Acta. 694 (1): 27–68. doi:10.1016/0304-4157(82)90013-2. PMID 6289898.
- Chiampanichayakul S, Szekeres A, Khunkaewla P, et al. (2003). "Engagement of Na,K-ATPase beta3 subunit by a specific mAb suppresses T and B lymphocyte activation". Int. Immunol. 14 (12): 1407–14. doi:10.1093/intimm/dxf112. PMID 12456588.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
- Chiampanichayakul S, Khunkaewla P, Pata S, Kasinrerk W (2007). "Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells". Tissue Antigens. 68 (6): 509–17. doi:10.1111/j.1399-0039.2006.00726.x. PMID 17176442.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Aughey RJ, Murphy KT, Clark SA, et al. (2007). "Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes". J. Appl. Physiol. 103 (1): 39–47. doi:10.1152/japplphysiol.00236.2006. PMID 17446412. S2CID 7370462.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
1–50 | |
---|
51–100 | |
---|
101–150 | |
---|
151–200 | |
---|
201–250 | |
---|
251–300 | |
---|
301–350 | |
---|
| This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |