CRIP1

Protein-coding gene in the species Homo sapiens
CRIP1
Identifiers
AliasesCRIP1, CRHP, CRIP, CRP-1, CRP1, cysteine rich protein 1
External IDsOMIM: 123875; MGI: 88501; HomoloGene: 37465; GeneCards: CRIP1; OMA:CRIP1 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for CRIP1
Genomic location for CRIP1
Band14q32.33Start105,486,317 bp[1]
End105,488,947 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for CRIP1
Genomic location for CRIP1
Band12 F1|12 61.59 cMStart113,109,936 bp[2]
End113,117,499 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right coronary artery

  • granulocyte

  • left coronary artery

  • popliteal artery

  • tibial arteries

  • olfactory zone of nasal mucosa

  • right uterine tube

  • ascending aorta

  • Descending thoracic aorta

  • duodenum
Top expressed in
  • left colon

  • crypt of lieberkuhn of small intestine

  • duodenum

  • ankle

  • tunica media of zone of aorta

  • gastrula

  • belly cord

  • carotid body

  • Paneth cell

  • decidua
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • peptide binding
  • DNA binding, bending
  • metal ion binding
  • minor groove of adenine-thymine-rich DNA binding
  • zinc ion binding
Cellular component
  • cytoplasm
Biological process
  • regulation of gene expression
  • prostate gland stromal morphogenesis
  • cellular response to antibiotic
  • heart development
  • response to zinc ion
  • cell population proliferation
  • cellular response to UV-B
  • response to organic substance
  • immune response
  • intrinsic apoptotic signaling pathway in response to DNA damage
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1396

12925

Ensembl

ENSG00000213145

ENSMUSG00000006360

UniProt

P50238

P63254

RefSeq (mRNA)

NM_001311

NM_007763

RefSeq (protein)

NP_001302

NP_031789

Location (UCSC)Chr 14: 105.49 – 105.49 MbChr 12: 113.11 – 113.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cysteine-rich protein 1 is a protein that in humans is encoded by the CRIP1 gene.[5][6]

Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991).[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213145 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006360 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Garcia-Barcelo M, Tsui SK, Chim SS, Fung KP, Lee CY, Waye MM (Apr 1998). "Mapping of the human cysteine-rich intestinal protein gene CRIP1 to the human chromosomal segment 7q11.23". Genomics. 47 (3): 419–422. doi:10.1006/geno.1997.5134. PMID 9480758.
  6. ^ a b "Entrez Gene: CRIP1 cysteine-rich protein 1 (intestinal)".
  • Human CRIP1 genome location and CRIP1 gene details page in the UCSC Genome Browser.

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Khoo C, Blanchard RK, Sullivan VK, Cousins RJ (1997). "Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells". Protein Expr. Purif. 9 (3): 379–387. doi:10.1006/prep.1996.0709. PMID 9126610.
  • Khoo C, Cousins RJ (1994). "Purification and properties of rat cysteine-rich intestinal protein". Biochem. J. 299 (2): 445–50. doi:10.1042/bj2990445. PMC 1138292. PMID 8172605.
  • Tsui SK, Yam NY, Lee CY, Waye MM (1995). "Isolation and characterization of a cDNA that codes for a LIM-containing protein which is developmentally regulated in heart". Biochem. Biophys. Res. Commun. 205 (1): 497–505. doi:10.1006/bbrc.1994.2693. PMID 7999070.
  • Hempe JM, Cousins RJ (1991). "Cysteine-rich intestinal protein binds zinc during transmucosal zinc transport". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9671–9674. Bibcode:1991PNAS...88.9671H. doi:10.1073/pnas.88.21.9671. PMC 52780. PMID 1946385.
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  • 1iml: CYSTEINE RICH INTESTINAL PROTEIN, NMR, 48 STRUCTURES
    1iml: CYSTEINE RICH INTESTINAL PROTEIN, NMR, 48 STRUCTURES


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