DYNLRB1

Protein-coding gene in the species Homo sapiens
DYNLRB1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1Z09, 2B95, 2E8J, 2HZ5

Identifiers
AliasesDYNLRB1, BITH, BLP, DNCL2A, DNLC2A, ROBLD1, dynein light chain roadblock-type 1
External IDsOMIM: 607167; MGI: 1914318; HomoloGene: 69161; GeneCards: DYNLRB1; OMA:DYNLRB1 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for DYNLRB1
Genomic location for DYNLRB1
Band20q11.22Start34,516,409 bp[1]
End34,540,958 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for DYNLRB1
Genomic location for DYNLRB1
Band2|2 H1Start155,078,453 bp[2]
End155,092,197 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 9

  • right frontal lobe

  • anterior cingulate cortex

  • right hemisphere of cerebellum

  • tibial nerve

  • C1 segment

  • islet of Langerhans

  • left coronary artery

  • popliteal artery

  • tibial arteries
Top expressed in
  • genital tubercle

  • supraoptic nucleus

  • tail of embryo

  • neural layer of retina

  • seminal vesicula

  • yolk sac

  • dentate gyrus of hippocampal formation granule cell

  • ascending aorta

  • aortic valve

  • ganglionic eminence
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • microtubule motor activity
  • cytoskeletal motor activity
  • dynein intermediate chain binding
Cellular component
  • centrosome
  • ciliary tip
  • cytoskeleton
  • membrane
  • cytoplasm
  • microtubule
  • cilium
  • cytoplasmic dynein complex
  • dynein complex
  • outer dynein arm
Biological process
  • visual behavior
  • microtubule-based movement
  • intraciliary transport involved in cilium assembly
  • transport
  • response to light stimulus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83658

67068

Ensembl

ENSG00000125971

ENSMUSG00000047459

UniProt

Q9NP97

P62627

RefSeq (mRNA)
NM_001281727
NM_001281728
NM_001281729
NM_014183
NM_177953

NM_001319157

NM_001291108
NM_025947

RefSeq (protein)

NP_001306086
NP_054902
NP_001369294
NP_001369295
NP_001369296

NP_001278037
NP_080223

Location (UCSC)Chr 20: 34.52 – 34.54 MbChr 2: 155.08 – 155.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.[5][6][7]

This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125971 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047459 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S (Dec 2001). "Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients". Gene. 281 (1–2): 103–13. doi:10.1016/S0378-1119(01)00787-9. PMID 11750132.
  6. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  7. ^ a b "Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1".

Further reading

  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Susalka SJ, Nikulina K, Salata MW, et al. (2002). "The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain". J. Biol. Chem. 277 (36): 32939–46. doi:10.1074/jbc.M205510200. PMID 12077152.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Huang YS, Carson JH, Barbarese E, Richter JD (2003). "Facilitation of dendritic mRNA transport by CPEB". Genes Dev. 17 (5): 638–53. doi:10.1101/gad.1053003. PMC 196011. PMID 12629046.
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Saito Y, Doi K, Yamagishi N, et al. (2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochem. Biophys. Res. Commun. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. PMID 14733918.
  • Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Campbell IG, Phillips WA, Choong DY (2006). "Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers". Clin. Cancer Res. 12 (12): 3713–5. doi:10.1158/1078-0432.CCR-06-0800. PMID 16778097. S2CID 24551435.
  • Pérez-González A, Rodriguez A, Huarte M, et al. (2007). "hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator". J. Mol. Biol. 362 (5): 887–900. doi:10.1016/j.jmb.2006.07.085. PMID 16950395.
  • Liu JF, Wang ZX, Wang XQ, et al. (2006). "Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74". Biochem. Biophys. Res. Commun. 349 (3): 1125–9. doi:10.1016/j.bbrc.2006.08.161. PMID 16970917.
  • Kang HC, Kim IJ, Kim K, et al. (2007). "km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers". Cancer Genet. Cytogenet. 175 (2): 173–4. doi:10.1016/j.cancergencyto.2007.02.004. PMID 17556076.
  • Wanschers B, van de Vorstenbosch R, Fransen J, et al. (2008). "Rab6 family proteins interact with the dynein light chain protein DYNLRB1". Cell Motil. Cytoskeleton. 65 (3): 183–96. doi:10.1002/cm.20254. PMID 18044744.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9NP97 (Dynein light chain roadblock-type 1) at the PDBe-KB.


  • v
  • t
  • e
  • 1y4o: Solution structure of a mouse cytoplasmic Roadblock/LC7 dynein light chain
    1y4o: Solution structure of a mouse cytoplasmic Roadblock/LC7 dynein light chain
  • 1z09: Solution structure of km23
    1z09: Solution structure of km23
  • 2b95: Solution NMR structure of protein dynein light chain 2A, cytoplasmic; Northeast structural genomics consortium TARGET HR2106
    2b95: Solution NMR structure of protein dynein light chain 2A, cytoplasmic; Northeast structural genomics consortium TARGET HR2106


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