Protein-coding gene in the species Homo sapiens
FOXQ1 |
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Identifiers |
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Aliases | FOXQ1, HFH1, forkhead box Q1 |
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External IDs | OMIM: 612788; MGI: 1298228; HomoloGene: 7359; GeneCards: FOXQ1; OMA:FOXQ1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 6 (human)[1] |
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| Band | 6p25.3 | Start | 1,312,098 bp[1] |
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End | 1,314,758 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 13 (mouse)[2] |
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| Band | 13 A3.2|13 13.46 cM | Start | 31,740,117 bp[2] |
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End | 31,744,959 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - parotid gland
- pylorus
- pancreatic epithelial cell
- pancreatic ductal cell
- endothelial cell
- skin of arm
- palpebral conjunctiva
- skin of hip
- secondary oocyte
- skin of thigh
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| Top expressed in | - transitional epithelium of urinary bladder
- conjunctival fornix
- pyloric antrum
- epithelium of stomach
- hair follicle
- mucous cell of stomach
- medullary collecting duct
- submandibular gland
- cornea
- duodenum
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - DNA-binding transcription factor activity
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Cellular component | | Biological process | - hair follicle morphogenesis
- regulation of transcription, DNA-templated
- transcription, DNA-templated
- negative regulation of transcription by RNA polymerase II
- anatomical structure morphogenesis
- cell differentiation
- regulation of transcription by RNA polymerase II
- negative regulation of neuron apoptotic process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 6: 1.31 – 1.31 Mb | Chr 13: 31.74 – 31.74 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Forkhead box Q1 is a protein that in humans is encoded by the FOXQ1 gene. [5]
Function
FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001 [PubMed 11747606]).
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164379 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038415 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Forkhead box Q1". Retrieved 2016-03-14.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.