Furafylline
Chemical compound
- None
- 3-(Furan-2-ylmethyl)-1,8-dimethyl-7H-purine-2,6-dione
- 80288-49-9 Y
- 3433
- 3315 N
- C2087G0XX3
- ChEMBL372638 N
- DTXSID2045153
- Interactive image
- Cc1[nH]c2c(n1)n(c(=O)n(c2=O)C)Cc3ccco3
InChI
- InChI=1S/C12H12N4O3/c1-7-13-9-10(14-7)16(6-8-4-3-5-19-8)12(18)15(2)11(9)17/h3-5H,6H2,1-2H3,(H,13,14) N
- Key:KGQZGCIVHYLPBH-UHFFFAOYSA-N N
Furafylline is a methylxanthine derivative that was introduced in hope of being a long-acting replacement for theophylline in the treatment of asthma.[1] It is an inhibitor of CYP1A2.[1]
References
- ^ a b Sesardic D, Boobis AR, Murray BP, Murray S, Segura J, de la Torre R, Davies DS (June 1990). "Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man". British Journal of Clinical Pharmacology. 29 (6): 651–63. doi:10.1111/j.1365-2125.1990.tb03686.x. PMC 1380167. PMID 2378786.
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Drugs for obstructive airway diseases: asthma/COPD (R03)
Short-acting β2 agonists | |
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Long-acting β2 agonists |
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Ultra-long-acting β2 agonists | |
Other |
muscarinic antagonist
Leukotriene antagonists | |
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Arachidonate 5-lipoxygenase inhibitors | |
Thromboxane receptor antagonists | |
Non-xanthine PDE4 inhibitors |
- Aclidinium bromide/formoterol
- Beclometasone/formoterol
- Beclometasone/formoterol/glycopyrronium bromide
- Budesonide/formoterol
- Budesonide/glycopyrronium bromide/formoterol
- Fluticasone furoate/umeclidinium bromide/vilanterol
- Fluticasone furoate/vilanterol
- Fluticasone propionate/salmeterol
- Glycopyrronium bromide/formoterol
- Indacaterol/glycopyrronium bromide
- Indacaterol/glycopyrronium bromide/mometasone
- Indacaterol/mometasone
- Ipratropium bromide/salbutamol
- Mometasone/formoterol
- Salbutamol (albuterol)/budesonide
- Theophylline/ephedrine
- Theophylline/ephedrine/hydroxyzine
- Theophylline/ephedrine/phenobarbital
- Umeclidinium bromide/vilanterol
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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