HARS2

Protein-coding gene in the species Homo sapiens
HARS2
Identifiers
AliasesHARS2, HARSL, HARSR, HO3, PRLTS2, histidyl-tRNA synthetase 2, mitochondrial, HisRS
External IDsOMIM: 600783; MGI: 1918041; HomoloGene: 40819; GeneCards: HARS2; OMA:HARS2 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for HARS2
Genomic location for HARS2
Band5q31.3Start140,691,430 bp[1]
End140,699,305 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for HARS2
Genomic location for HARS2
Band18|18 B2Start36,916,061 bp[2]
End36,925,615 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • apex of heart

  • granulocyte

  • mucosa of transverse colon

  • right adrenal cortex

  • rectum

  • right uterine tube

  • body of uterus

  • right ovary
Top expressed in
  • neural layer of retina

  • ventricular zone

  • spermatocyte

  • superior frontal gyrus

  • right kidney

  • primary visual cortex

  • granulocyte

  • thymus

  • proximal tubule

  • cerebellar cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • aminoacyl-tRNA ligase activity
  • nucleotide binding
  • ligase activity
  • protein binding
  • ATP binding
  • protein homodimerization activity
  • histidine-tRNA ligase activity
  • RNA binding
  • identical protein binding
Cellular component
  • cytoplasm
  • mitochondrial matrix
  • mitochondrion
  • cytosol
Biological process
  • protein biosynthesis
  • histidyl-tRNA aminoacylation
  • mitochondrial translation
  • tRNA aminoacylation for protein translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23438

70791

Ensembl

ENSG00000112855

ENSMUSG00000019143

UniProt

P49590

Q99KK9

RefSeq (mRNA)

NM_001278731
NM_001278732
NM_012208
NM_001363535
NM_001363536

NM_080636
NM_001305627
NM_001360921

RefSeq (protein)

NP_001265660
NP_001265661
NP_036340
NP_001350464
NP_001350465

NP_001292556
NP_542367
NP_001347850

Location (UCSC)Chr 5: 140.69 – 140.7 MbChr 18: 36.92 – 36.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable histidyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the HARS2 gene.[5][6]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112855 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019143 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ O'Hanlon TP, Raben N, Miller FW (Jun 1995). "A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS". Biochem Biophys Res Commun. 210 (2): 556–66. doi:10.1006/bbrc.1995.1696. PMID 7755634.
  6. ^ a b "Entrez Gene: HARS2 histidyl-tRNA synthetase 2, mitochondrial (putative)".

Further reading

  • Freist W, Verhey JF, Rühlmann A, et al. (1999). "Histidyl-tRNA synthetase". Biol. Chem. 380 (6): 623–46. doi:10.1515/BC.1999.079. PMID 10430027.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lama J, Trono D (1998). "Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3". J. Virol. 72 (2): 1671–6. doi:10.1128/JVI.72.2.1671-1676.1998. PMC 124654. PMID 9445076.
  • Tsui HW, Mok S, de Souza L, et al. (1993). "Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element". Gene. 131 (2): 201–8. doi:10.1016/0378-1119(93)90294-D. PMID 8406012.
  • Raben N, Borriello F, Amin J, et al. (1992). "Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases". Nucleic Acids Res. 20 (5): 1075–81. doi:10.1093/nar/20.5.1075. PMC 312093. PMID 1549469.


  • v
  • t
  • e