ISG20 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | ISG20, CD25, HEM45, interferon stimulated exonuclease gene 20kDa, interferon stimulated exonuclease gene 20 |
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External IDs | OMIM: 604533; MGI: 1928895; HomoloGene: 31081; GeneCards: ISG20; OMA:ISG20 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 15 (human)[1] |
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| Band | 15q26.1 | Start | 88,635,670 bp[1] |
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End | 88,656,483 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7|7 D2 | Start | 78,563,172 bp[2] |
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End | 78,570,144 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - spleen
- blood
- granulocyte
- lymph node
- cartilage tissue
- appendix
- duodenum
- jejunal mucosa
- epithelium of nasopharynx
- right lung
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| Top expressed in | - tibiofemoral joint
- blood
- spermatid
- islet of Langerhans
- spleen
- decidua
- right lung lobe
- gastrula
- thymus
- fetal liver hematopoietic progenitor cell
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - 3'-5'-exoribonuclease activity
- single-stranded DNA 3'-5' exodeoxyribonuclease activity
- exoribonuclease II activity
- metal ion binding
- U3 snoRNA binding
- U2 snRNA binding
- RNA binding
- nucleic acid binding
- U1 snRNA binding
- nuclease activity
- exonuclease activity
- hydrolase activity
| Cellular component | - cytoplasm
- Cajal body
- PML body
- nucleoplasm
- nucleolus
- nucleus
| Biological process | - immune system process
- response to virus
- RNA catabolic process
- negative regulation of viral genome replication
- DNA catabolic process, exonucleolytic
- defense response to virus
- type I interferon signaling pathway
- rRNA processing
- innate immune response
- cell population proliferation
- RNA phosphodiester bond hydrolysis, exonucleolytic
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001303233 NM_001303234 NM_001303235 NM_001303236 NM_001303237
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NM_002201 |
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NM_001113527 NM_001291220 NM_001291221 NM_020583 |
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RefSeq (protein) | NP_001290162 NP_001290163 NP_001290164 NP_001290165 NP_001290166
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NP_002192 |
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NP_001106999 NP_001278149 NP_001278150 NP_065608 |
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Location (UCSC) | Chr 15: 88.64 – 88.66 Mb | Chr 7: 78.56 – 78.57 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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