LMAN2

Protein-coding gene in the species Homo sapiens
LMAN2
Identifiers
AliasesLMAN2, C5orf8, GP36B, VIP36, lectin, mannose binding 2
External IDsOMIM: 609551; MGI: 1914140; HomoloGene: 4962; GeneCards: LMAN2; OMA:LMAN2 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for LMAN2
Genomic location for LMAN2
Band5q35.3Start177,315,805 bp[1]
End177,351,840 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for LMAN2
Genomic location for LMAN2
Band13|13 B1Start55,491,646 bp[2]
End55,510,596 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • body of pancreas

  • right lobe of liver

  • mucosa of esophagus

  • granulocyte

  • gallbladder

  • mucosa of transverse colon

  • right lobe of thyroid gland

  • monocyte

  • left lobe of thyroid gland
Top expressed in
  • spermatid

  • right kidney

  • spermatocyte

  • decidua

  • yolk sac

  • proximal tubule

  • brown adipose tissue

  • lacrimal gland

  • islet of Langerhans

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • mannose binding
  • heat shock protein binding
  • metal ion binding
  • carbohydrate binding
  • protein binding
Cellular component
  • integral component of membrane
  • cell surface
  • Golgi apparatus
  • integral component of plasma membrane
  • extracellular exosome
  • endoplasmic reticulum-Golgi intermediate compartment membrane
  • endoplasmic reticulum
  • membrane
  • endoplasmic reticulum-Golgi intermediate compartment
  • extracellular space
  • Golgi membrane
  • endoplasmic reticulum membrane
  • COPII-coated ER to Golgi transport vesicle
Biological process
  • protein transport
  • positive regulation of phagocytosis
  • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
  • transport
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • endoplasmic reticulum organization
  • Golgi organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10960

66890

Ensembl

ENSG00000169223

ENSMUSG00000021484

UniProt

Q12907

Q9DBH5

RefSeq (mRNA)

NM_006816

NM_025828

RefSeq (protein)

NP_006807

NP_080104

Location (UCSC)Chr 5: 177.32 – 177.35 MbChr 13: 55.49 – 55.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vesicular integral-membrane protein VIP36 is a protein that in humans is encoded by the LMAN2 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169223 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021484 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nufer O, Mitrovic S, Hauri HP (Apr 2003). "Profile-based data base scanning for animal L-type lectins and characterization of VIPL, a novel VIP36-like endoplasmic reticulum protein". J Biol Chem. 278 (18): 15886–96. doi:10.1074/jbc.M211199200. PMID 12609988.
  6. ^ "Entrez Gene: LMAN2 lectin, mannose-binding 2".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Füllekrug J, Scheiffele P, Simons K (1999). "VIP36 localisation to the early secretory pathway". J. Cell Sci. 112 (17): 2813–21. doi:10.1242/jcs.112.17.2813. PMID 10444376.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
  • Søborg C, Madsen HO, Andersen AB, et al. (2003). "Mannose-binding lectin polymorphisms in clinical tuberculosis". J. Infect. Dis. 188 (5): 777–82. doi:10.1086/377183. PMID 12934195.
  • Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nawa D, Shimada O, Kawasaki N, et al. (2007). "Stable interaction of the cargo receptor VIP36 with molecular chaperone BiP". Glycobiology. 17 (9): 913–21. doi:10.1093/glycob/cwm067. PMID 17586539.


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