MGST2

Protein-coding gene in the species Homo sapiens
MGST2
Identifiers
AliasesMGST2, GST2, MGST-II, microsomal glutathione S-transferase 2
External IDsOMIM: 601733; MGI: 2448481; HomoloGene: 1811; GeneCards: MGST2; OMA:MGST2 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for MGST2
Genomic location for MGST2
Band4q31.1Start139,665,768 bp[1]
End139,740,745 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for MGST2
Genomic location for MGST2
Band3|3 CStart51,567,781 bp[2]
End51,590,098 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • secondary oocyte

  • mucosa of esophagus

  • rectum

  • right lobe of liver

  • gallbladder

  • olfactory zone of nasal mucosa

  • right adrenal cortex

  • left adrenal gland

  • apex of heart
Top expressed in
  • gastric mucosa

  • epithelium of stomach

  • mucous cell of stomach

  • pyloric antrum

  • granulocyte

  • duodenum

  • Paneth cell

  • jejunum

  • ileum

  • left colon
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • enzyme activator activity
  • leukotriene-C4 synthase activity
  • transferase activity
  • glutathione transferase activity
  • protein binding
  • glutathione peroxidase activity
Cellular component
  • integral component of membrane
  • intracellular membrane-bounded organelle
  • organelle membrane
  • plasma membrane
  • cytoplasm
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • nuclear envelope
  • membrane
Biological process
  • glutathione derivative biosynthetic process
  • leukotriene metabolic process
  • leukotriene biosynthetic process
  • glutathione biosynthetic process
  • response to lipopolysaccharide
  • positive regulation of catalytic activity
  • response to organonitrogen compound
  • xenobiotic metabolic process
  • cellular oxidant detoxification
  • lipid metabolism
  • membrane lipid catabolic process
  • positive regulation of inflammatory response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4258

211666

Ensembl

ENSG00000085871

ENSMUSG00000074604

UniProt

Q99735

A2RST1

RefSeq (mRNA)

NM_001204366
NM_001204367
NM_001204368
NM_002413

NM_174995
NM_001310482

RefSeq (protein)

NP_001191295
NP_001191296
NP_001191297
NP_002404

NP_001297411
NP_778160

Location (UCSC)Chr 4: 139.67 – 139.74 MbChr 3: 51.57 – 51.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Microsomal glutathione S-transferase 2 is an enzyme that in humans is encoded by the MGST2 gene.[5][6]

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000085871 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074604 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jakobsson PJ, Mancini JA, Ford-Hutchinson AW (Oct 1996). "Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase". J Biol Chem. 271 (36): 22203–10. doi:10.1074/jbc.271.36.22203. PMID 8703034.
  6. ^ a b "Entrez Gene: MGST2 microsomal glutathione S-transferase 2".

Further reading

  • Jakobsson PJ, Morgenstern R, Mancini J, et al. (2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20–4. doi:10.1164/ajrccm.161.supplement_1.ltta-5. PMID 10673221.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW (1997). "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities". J. Biol. Chem. 272 (36): 22934–9. doi:10.1074/jbc.272.36.22934. PMID 9278457.
  • Jakobsson PJ, Scoggan KA, Yergey J, et al. (1998). "Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer". Journal of Lipid Mediators and Cell Signalling. 17 (1): 15–9. doi:10.1016/S0929-7855(97)00013-8. PMID 9302651.
  • Sjöström M, Jakobsson PJ, Heimburger M, et al. (2001). "Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor". Eur. J. Biochem. 268 (9): 2578–86. doi:10.1046/j.1432-1327.2001.02142.x. PMID 11322876.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yang S, Yan KL, Zhang XJ, et al. (2006). "Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population". Arch. Dermatol. Res. 298 (3): 107–12. doi:10.1007/s00403-006-0670-4. PMID 16773312. S2CID 20923145.


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