Nucleoporin 188

Protein-coding gene in the species Homo sapiens
NUP188
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5IJO

Identifiers
AliasesNUP188, KIAA0169, hNup188, nucleoporin 188kDa, nucleoporin 188, SANDSTEF
External IDsOMIM: 615587; MGI: 2446190; HomoloGene: 45683; GeneCards: NUP188; OMA:NUP188 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for NUP188
Genomic location for NUP188
Band9q34.11Start128,947,699 bp[1]
End129,007,096 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for NUP188
Genomic location for NUP188
Band2|2 BStart30,176,409 bp[2]
End30,234,278 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • anterior pituitary

  • testicle

  • stromal cell of endometrium

  • skin of leg

  • gastric mucosa

  • ectocervix
Top expressed in
  • spermatocyte

  • spermatid

  • seminiferous tubule

  • epiblast

  • tail of embryo

  • ventricular zone

  • Gonadal ridge

  • zygote

  • maxillary prominence

  • mandibular prominence
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • structural constituent of nuclear pore
Cellular component
  • nuclear pore
  • nucleus
  • nuclear pore inner ring
  • nuclear envelope
  • membrane
  • host cell
Biological process
  • mitotic nuclear membrane disassembly
  • viral transcription
  • protein import into nucleus
  • viral process
  • RNA export from nucleus
  • protein sumoylation
  • protein transport
  • mRNA transport
  • regulation of cellular response to heat
  • intracellular transport of virus
  • glomerular visceral epithelial cell migration
  • mRNA export from nucleus
  • tRNA export from nucleus
  • regulation of gene silencing by miRNA
  • regulation of glycolytic process
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23511

227699

Ensembl

ENSG00000095319

ENSMUSG00000052533

UniProt

Q5SRE5

Q6ZQH8

RefSeq (mRNA)

NM_015354

NM_198304

RefSeq (protein)

NP_056169

NP_938046

Location (UCSC)Chr 9: 128.95 – 129.01 MbChr 2: 30.18 – 30.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleoporin 188 (Nup188) is a protein that in humans is encoded by the NUP188 gene.[5][6]

Function

Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP188 is part of one such subcomplex.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000095319 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052533 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: NUP188 nucleoporin 188kDa".
  6. ^ Miller BR, Powers M, Park M, Fischer W, Forbes DJ (October 2000). "Identification of a New Vertebrate Nucleoporin, Nup188, with the Use of a Novel Organelle Trap Assay". Mol. Biol. Cell. 11 (10): 3381–96. doi:10.1091/mbc.11.10.3381. PMC 15000. PMID 11029043.
  • Overview of all the structural information available in the PDB for UniProt: Q5SRE5 (Human Nucleoporin NUP188 homolog (NUP188)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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