Protein-coding gene in the species Homo sapiens
SLC51B |
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Identifiers |
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Aliases | SLC51B, OSTB, OSTBETA, OSTbeta, solute carrier family 51 beta subunit, solute carrier family 51 subunit beta, PBAM2 |
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External IDs | OMIM: 612085; MGI: 3582052; HomoloGene: 18721; GeneCards: SLC51B; OMA:SLC51B - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 15 (human)[1] |
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| Band | 15q22.31 | Start | 65,045,387 bp[1] |
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End | 65,053,397 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 9 (mouse)[2] |
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| Band | 9|9 C | Start | 65,319,996 bp[2] |
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End | 65,330,237 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - mucosa of ileum
- mucosa of transverse colon
- duodenum
- rectum
- jejunal mucosa
- testicle
- mucosa of sigmoid colon
- popliteal artery
- tibial arteries
- right coronary artery
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| Top expressed in | - jejunum
- ileum
- epithelium of small intestine
- right kidney
- proximal tubule
- duodenum
- human kidney
- Paneth cell
- large intestine
- colon
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - transporter activity
- protein heterodimerization activity
- bile acid transmembrane transporter activity
- transmembrane transporter activity
| Cellular component | - integral component of membrane
- plasma membrane
- membrane
- basolateral plasma membrane
- protein-containing complex
| Biological process | - positive regulation of protein glycosylation
- regulation of protein stability
- positive regulation of protein exit from endoplasmic reticulum
- bile acid and bile salt transport
- positive regulation of protein targeting to membrane
- bile acid secretion
- transmembrane transport
- organic substance transport
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 15: 65.05 – 65.05 Mb | Chr 9: 65.32 – 65.33 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.[5][6]
Function
OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.[6][7] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.[7] The heterodimer furthermore is essential for intestinal bile acid transport.[8]
OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.[6]
See also
- OSTalpha
- OST Family
- Transporter Classification Database
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000186198 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053862 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: OSTbeta organic solute transporter beta".
- ^ a b c Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi:10.1074/jbc.M301106200. PMID 12719432.
- ^ a b Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi:10.1074/jbc.M412752200. PMC 1224727. PMID 15563450.
- ^ Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. Bibcode:2008PNAS..105.3891R. doi:10.1073/pnas.0712328105. PMC 2268840. PMID 18292224.
Further reading
- Sun AQ, Balasubramaniyan N, Xu K, et al. (2007). "Protein-protein interactions and membrane localization of the human organic solute transporter". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (6): G1586–93. doi:10.1152/ajpgi.00457.2006. PMID 17332473.
- Boyer JL, Trauner M, Mennone A, et al. (2006). "Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (6): G1124–30. doi:10.1152/ajpgi.00539.2005. PMID 16423920. S2CID 86156271.
- Ballatori N, Christian WV, Lee JY, et al. (2005). "OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia". Hepatology. 42 (6): 1270–9. doi:10.1002/hep.20961. PMID 16317684.
- Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA (2006). "The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (3): G476–85. doi:10.1152/ajpgi.00430.2005. PMID 16269519. S2CID 8687386.
- Lee H, Zhang Y, Lee FY, et al. (2006). "FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine". J. Lipid Res. 47 (1): 201–14. doi:10.1194/jlr.M500417-JLR200. PMID 16251721.
- Dawson PA, Hubbert M, Haywood J, et al. (2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi:10.1074/jbc.M412752200. PMC 1224727. PMID 15563450.
- Seward DJ, Koh AS, Boyer JL, Ballatori N (2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi:10.1074/jbc.M301106200. PMID 12719432.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.