Protein-coding gene in the species Homo sapiens
PCID2 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | PCID2, F10, PCI domain containing 2 |
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External IDs | OMIM: 613713; MGI: 2443003; HomoloGene: 10168; GeneCards: PCID2; OMA:PCID2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 13 (human)[1] |
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| Band | 13q34 | Start | 113,177,536 bp[1] |
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End | 113,208,715 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 8 (mouse)[2] |
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| Band | 8|8 A1.1 | Start | 13,127,189 bp[2] |
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End | 13,155,459 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - oocyte
- secondary oocyte
- left ovary
- right ovary
- left testis
- right testis
- canal of the cervix
- body of uterus
- cerebellar hemisphere
- right hemisphere of cerebellum
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| Top expressed in | - Ileal epithelium
- perirhinal cortex
- entorhinal cortex
- choroid plexus of fourth ventricle
- lactiferous gland
- otic placode
- CA3 field
- otic vesicle
- saccule
- internal carotid artery
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - protein binding
- double-stranded DNA binding
- RNA binding
| Cellular component | - nuclear pore
- transcription export complex 2
- cellular component
- nucleus
- cytoplasm
- nuclear pore nuclear basket
| Biological process | - positive regulation of B cell differentiation
- positive regulation of transcription, DNA-templated
- positive regulation of mitotic cell cycle spindle assembly checkpoint
- negative regulation of apoptotic process
- spleen development
- regulation of mRNA stability
- negative regulation of cysteine-type endopeptidase activity
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
- transcription elongation from RNA polymerase II promoter
- poly(A)+ mRNA export from nucleus
- protein transport
- mRNA transport
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001127202 NM_001127203 NM_001258212 NM_001258213 NM_018386
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NM_001320655 NM_001320656 NM_001320657 NM_001320659 NM_001320660 NM_001353091 NM_001353092 NM_001353093 NM_001353094 NM_001353095 |
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RefSeq (protein) | NP_001120674 NP_001120675 NP_001245142 NP_001307584 NP_001307585
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NP_001307586 NP_001307588 NP_001307589 NP_060856 NP_001340020 NP_001340021 NP_001340022 NP_001340023 NP_001340024 |
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Location (UCSC) | Chr 13: 113.18 – 113.21 Mb | Chr 8: 13.13 – 13.16 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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PCI domain containing 2 is a protein that in humans is encoded by the PCID2 gene. [5]
Function
This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000126226 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038542 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: PCI domain containing 2". Retrieved 2017-12-13.
Further reading
- Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
- Ye B, Dai Z, Liu B, Wang R, Li C, Huang G, Wang S, Xia P, Yang X, Kuwahara K, Sakaguchi N, Fan Z (2014). "Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability". Stem Cells. 32 (3): 623–35. doi:10.1002/stem.1580. PMID 24167073.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.