PELI2

Protein-coding gene in the species Homo sapiens
PELI2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3EGA, 3EGB

Identifiers
AliasesPELI2, pellino E3 ubiquitin protein ligase family member 2
External IDsOMIM: 614798; MGI: 1891445; HomoloGene: 41431; GeneCards: PELI2; OMA:PELI2 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for PELI2
Genomic location for PELI2
Band14q22.3Start56,117,814 bp[1]
End56,301,524 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for PELI2
Genomic location for PELI2
Band14 C1|14 24.6 cMStart48,358,280 bp[2]
End48,519,032 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • testicle

  • ganglionic eminence

  • Achilles tendon

  • jejunal mucosa

  • monocyte

  • body of pancreas

  • metanephric glomerulus

  • blood

  • sural nerve
Top expressed in
  • basilar part of occipital bone

  • spermatid

  • fibula

  • splanchnocranium

  • seminiferous tubule

  • spermatocyte

  • Meckel's cartilage

  • sciatic nerve

  • ascending aorta

  • aortic valve
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • ubiquitin-ubiquitin ligase activity
  • protein serine/threonine kinase activity
  • transferase activity
  • ubiquitin protein ligase activity
Cellular component
  • cytosol
Biological process
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • positive regulation of protein phosphorylation
  • protein ubiquitination
  • positive regulation of MAPK cascade
  • protein polyubiquitination
  • protein phosphorylation
  • immune response
  • Toll signaling pathway
  • interleukin-1-mediated signaling pathway
  • regulation of Toll signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57161

93834

Ensembl

ENSG00000139946

ENSMUSG00000021846

UniProt

Q9HAT8

Q8BST6

RefSeq (mRNA)

NM_021255

NM_033602

RefSeq (protein)

NP_067078

NP_291080

Location (UCSC)Chr 14: 56.12 – 56.3 MbChr 14: 48.36 – 48.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139946 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021846 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Resch K, Jockusch H, Schmitt-John T (Apr 2001). "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 172–4. doi:10.1159/000056895. PMID 11306823. S2CID 83911010.
  6. ^ Strelow A, Kollewe C, Wesche H (Jul 2003). "Characterization of Pellino2, a substrate of IRAK1 and IRAK4". FEBS Lett. 547 (1–3): 157–61. doi:10.1016/S0014-5793(03)00697-5. PMID 12860405.
  7. ^ "Entrez Gene: PELI2 pellino homolog 2 (Drosophila)".

Further reading

  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Liu Y, Dong W, Chen L, et al. (2004). "BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2". J. Biol. Chem. 279 (36): 37436–44. doi:10.1074/jbc.M400241200. PMID 15213237.
  • Jensen LE, Whitehead AS (2003). "Pellino2 activates the mitogen activated protein kinase pathway". FEBS Lett. 545 (2–3): 199–202. doi:10.1016/S0014-5793(03)00533-7. PMID 12804775.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yu KY, Kwon HJ, Norman DA, et al. (2002). "Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling". J. Immunol. 169 (8): 4075–8. doi:10.4049/jimmunol.169.8.4075. PMID 12370331.


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