Protein-coding gene in the species Homo sapiens
PIGW |
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Identifiers |
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Aliases | PIGW, Gwt1, HPMRS5, phosphatidylinositol glycan anchor biosynthesis class W |
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External IDs | OMIM: 610275; MGI: 1917575; HomoloGene: 6243; GeneCards: PIGW; OMA:PIGW - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 17 (human)[1] |
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| Band | 17q12 | Start | 36,534,987 bp[1] |
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End | 36,539,310 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11|11 C | Start | 84,767,141 bp[2] |
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End | 84,771,111 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - islet of Langerhans
- endometrium
- gastrocnemius muscle
- testicle
- appendix
- rectum
- skeletal muscle tissue
- mucosa of esophagus
- lymph node
- gonad
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| Top expressed in | - epiblast
- lens
- quadriceps femoris muscle
- hepatobiliary system
- liver
- muscle of thigh
- white adipose tissue
- ileum
- yolk sac
- tail of embryo
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - acyltransferase activity
- transferase activity
- O-acyltransferase activity
- glucosaminyl-phosphatidylinositol O-acyltransferase activity
| Cellular component | - membrane
- endoplasmic reticulum membrane
- integral component of membrane
- endoplasmic reticulum
| Biological process | - GPI anchor biosynthetic process
- GPI anchor metabolic process
- protein localization to plasma membrane
- preassembly of GPI anchor in ER membrane
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000275600 ENSG00000277161 |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_178517 NM_001346754 NM_001346755 |
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NM_001077636 NM_027388 NM_001363112 |
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RefSeq (protein) | |
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NP_001333683 NP_001333684 NP_848612 |
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NP_001071104 NP_081664 NP_001350041 |
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Location (UCSC) | Chr 17: 36.53 – 36.54 Mb | Chr 11: 84.77 – 84.77 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Phosphatidylinositol glycan anchor biosynthesis class W is a protein that in humans is encoded by the PIGW gene. [5]
Function
Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. PIGW acts in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol (Murakami et al., 2003 [PubMed 14517336]).
References
- ^ a b c ENSG00000277161 GRCh38: Ensembl release 89: ENSG00000275600, ENSG00000277161 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045140 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Phosphatidylinositol glycan anchor biosynthesis class W". Retrieved 2016-10-29.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.