PRSS22

Protein-coding gene in the species Homo sapiens
PRSS22
Identifiers
AliasesPRSS22, BSSP-4, hBSSP-4, SP001LA, protease, serine 22, serine protease 22
External IDsOMIM: 609343; MGI: 1918085; HomoloGene: 23344; GeneCards: PRSS22; OMA:PRSS22 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for PRSS22
Genomic location for PRSS22
Band16p13.3Start2,852,730 bp[1]
End2,858,170 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for PRSS22
Genomic location for PRSS22
Band17 A3.3|17 12.18 cMStart24,212,508 bp[2]
End24,217,074 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • olfactory zone of nasal mucosa

  • minor salivary glands

  • gallbladder

  • body of pancreas

  • right uterine tube

  • prostate

  • tonsil

  • vagina

  • right lobe of thyroid gland

  • left lobe of thyroid gland
Top expressed in
  • conjunctival fornix

  • lip

  • transitional epithelium of urinary bladder

  • cornea

  • superior cervical ganglion

  • epithelium of lens

  • external carotid artery

  • esophagus

  • internal carotid artery

  • ciliary body
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • peptidase activity
  • serine-type endopeptidase activity
  • hydrolase activity
  • serine-type peptidase activity
Cellular component
  • extracellular region
  • extrinsic component of plasma membrane
  • anchored component of plasma membrane
Biological process
  • proteolysis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64063

70835

Ensembl

ENSG00000005001
ENSG00000282937

ENSMUSG00000045027

UniProt

Q9GZN4

Q9ER10

RefSeq (mRNA)

NM_022119

NM_133731

RefSeq (protein)

NP_071402

NP_598492

Location (UCSC)Chr 16: 2.85 – 2.86 MbChr 17: 24.21 – 24.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene.[5][6][7]

This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16.[5]

See also

References

  1. ^ a b c ENSG00000282937 GRCh38: Ensembl release 89: ENSG00000005001, ENSG00000282937 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045027 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: protease".
  6. ^ Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL (December 2001). "Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells". J. Biol. Chem. 276 (52): 49169–82. doi:10.1074/jbc.M108677200. PMID 11602603.
  7. ^ Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL (May 2005). "Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22". Blood. 105 (10): 3893–901. doi:10.1182/blood-2003-10-3501. PMC 1895090. PMID 15701722.

Further reading

  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Martin J, Han C, Gordon LA, et al. (2004). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553.
  • Mitsui S, Okui A, Kominami K, et al. (2005). "A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells". FEBS J. 272 (19): 4911–23. doi:10.1111/j.1742-4658.2005.04901.x. PMID 16176265. S2CID 25290079.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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