GCG |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1BH0, 1NAU, 2G49, 2M5P, 2M5Q,%%s4ZGM, 4APD, 3IOL, 1D0R,%%s2L64, 2L63 |
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Identifiers |
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Aliases | GCG, GLP1, glucagon, GRPP, GLP-1, GLP2 |
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External IDs | OMIM: 138030; MGI: 95674; HomoloGene: 136497; GeneCards: GCG; OMA:GCG - orthologs |
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Gene location (Human) |
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![Chromosome 2 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/300px-Ideogram_human_chromosome_2.svg.png) | Chr. | Chromosome 2 (human)[1] |
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| Band | 2q24.2 | Start | 162,142,882 bp[1] |
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End | 162,152,404 bp[1] |
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Gene location (Mouse) |
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![Chromosome 2 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2 C1.3|2 35.85 cM | Start | 62,304,874 bp[2] |
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End | 62,313,994 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - beta cell
- body of pancreas
- rectum
- mucosa of sigmoid colon
- mucosa of ileum
- testicle
- mucosa of transverse colon
- epithelium of colon
- jejunal mucosa
- appendix
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| Top expressed in | - islet of Langerhans
- crypt of lieberkuhn of small intestine
- ileum
- large intestine
- colon
- lens
- Paneth cell
- left colon
- jejunum
- epithelium of small intestine
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/8/89/PBB_GE_GCG_206422_at_fs.png/250px-PBB_GE_GCG_206422_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - protein binding
- identical protein binding
- hormone activity
- glucagon receptor binding
- signaling receptor binding
| Cellular component | - cytoplasm
- endoplasmic reticulum lumen
- extracellular region
- secretory granule lumen
- extracellular space
| Biological process | - negative regulation of execution phase of apoptosis
- G protein-coupled receptor signaling pathway
- regulation of insulin secretion
- cellular response to glucagon stimulus
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of calcium ion import
- positive regulation of histone H3-K4 methylation
- positive regulation of peptidyl-threonine phosphorylation
- feeding behavior
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein binding
- cell population proliferation
- signal transduction
- positive regulation of protein kinase activity
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway
- protein kinase A signaling
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- response to starvation
- negative regulation of apoptotic process
- regulation of signaling receptor activity
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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