SN-22

Chemical compound

SN-22
Identifiers
  • 3-(1-methylpiperidin-4-yl)-1H-indole
CAS Number
  • 17403-07-5 checkY[pubchem]
PubChem CID
  • 11206672
ChemSpider
  • 9381734 checkY
UNII
  • 7NSM99C49F
ChEMBL
  • ChEMBL341485
CompTox Dashboard (EPA)
  • DTXSID90169751 Edit this at Wikidata
Chemical and physical data
FormulaC14H18N2
Molar mass214.312 g·mol−1
3D model (JSmol)
  • Interactive image
  • CN1CCC(CC1)c1c[nH]c2c1cccc2
InChI
  • InChI=1S/C14H18N2/c1-16-8-6-11(7-9-16)13-10-15-14-5-3-2-4-12(13)14/h2-5,10-11,15H,6-9H2,1H3
  • Key:KYSCKYJNMTUJPA-UHFFFAOYSA-N

SN-22 is a chemical compound which acts as a moderately selective agonist at the 5-HT2 family of serotonin receptors, with a Ki of 19 nM at 5-HT2 subtypes versus 514 nM at 5-HT1A receptors.[1] Many related derivatives are known, most of which are ligands for 5-HT1A, 5-HT6 or dopamine D2 receptors or show SSRI activity.[2][3][4][5][6]

See also

References

  1. ^ Taylor EW, Nikam SS, Lambert G, Martin AR, Nelson DL (July 1988). "Molecular determinants for recognition of RU 24969 analogs at central 5-hydroxytryptamine recognition sites: use of a bilinear function and substituent volumes to describe steric fit". Molecular Pharmacology. 34 (1): 42–53. PMID 3393140.
  2. ^ Agarwal A, Pearson PP, Taylor EW, Li HB, Dahlgren T, Herslöf M, et al. (December 1993). "Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods". Journal of Medicinal Chemistry. 36 (25): 4006–14. doi:10.1021/jm00077a003. PMID 8258822.
  3. ^ Cole DC, Ellingboe JW, Lennox WJ, Mazandarani H, Smith DL, Stock JR, et al. (January 2005). "N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists". Bioorganic & Medicinal Chemistry Letters. 15 (2): 379–83. doi:10.1016/j.bmcl.2004.10.064. PMID 15603958.
  4. ^ Deskus JA, Epperson JR, Sloan CP, Cipollina JA, Dextraze P, Qian-Cutrone J, et al. (June 2007). "Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors". Bioorganic & Medicinal Chemistry Letters. 17 (11): 3099–104. doi:10.1016/j.bmcl.2007.03.040. PMID 17391962.
  5. ^ Mattsson C, Andreasson T, Waters N, Sonesson C (November 2012). "Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach". Journal of Medicinal Chemistry. 55 (22): 9735–50. doi:10.1021/jm300975f. PMID 23043306.
  6. ^ US 6046215, "Inhibition of serotonin reuptake" 
  • v
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5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
  • See also: Receptor/signaling modulators
  • Adrenergics
  • Dopaminergics
  • Melatonergics
  • Monoamine reuptake inhibitors and releasing agents
  • Monoamine metabolism modulators
  • Monoamine neurotoxins
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