Protein-coding gene in the species Homo sapiens
TCF15 |
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Identifiers |
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Aliases | TCF15, EC2, PARAXIS, bHLHa40, transcription factor 15 (basic helix-loop-helix), transcription factor 15 |
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External IDs | OMIM: 601010; MGI: 104664; HomoloGene: 37943; GeneCards: TCF15; OMA:TCF15 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 20 (human)[1] |
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| Band | 20p13 | Start | 604,257 bp[1] |
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End | 610,309 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2 G3|2 74.83 cM | Start | 151,985,481 bp[2] |
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End | 151,991,017 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right ventricle
- apex of heart
- vena cava
- glutes
- Skeletal muscle tissue of biceps brachii
- dorsal motor nucleus of vagus nerve
- Skeletal muscle tissue of rectus abdominis
- body of tongue
- left ventricle
- gonad
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| Top expressed in | - somite
- digastric muscle
- sclerotome
- sternocleidomastoid muscle
- masseter muscle
- tibialis anterior muscle
- intercostal muscle
- interventricular septum
- myocardium of ventricle
- triceps brachii muscle
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - DNA binding
- protein dimerization activity
- DNA-binding transcription factor activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Cellular component | - nucleus
- RNA polymerase II transcription regulator complex
| Biological process | - somitogenesis
- respiratory system process
- regulation of transcription, DNA-templated
- muscle organ morphogenesis
- eating behavior
- neuromuscular process controlling posture
- regulation of transcription by RNA polymerase II
- skeletal system morphogenesis
- muscle organ development
- ear development
- transcription, DNA-templated
- multicellular organism development
- establishment of epithelial cell apical/basal polarity
- regulation of extracellular matrix organization
- post-anal tail morphogenesis
- regulation of gene expression
- mesoderm development
- anterior/posterior pattern specification
- skin development
- paraxial mesoderm development
- mesenchymal to epithelial transition
- transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 20: 0.6 – 0.61 Mb | Chr 2: 151.99 – 151.99 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Transcription factor 15 is a protein that in humans is encoded by the TCF15 gene. [5]
Function
The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000125878 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068079 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Transcription factor 15". Retrieved 2017-11-09.
Further reading
- Guo P, Zhao KW, Dong XY, Sun X, Dong JT (2009). "Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells". J. Biol. Chem. 284 (27): 18184–93. doi:10.1074/jbc.M109.007096. PMC 2709394. PMID 19419955.
- Coppiello G, Collantes M, Sirerol-Piquer MS, Vandenwijngaert S, Schoors S, Swinnen M, Vandersmissen I, Herijgers P, Topal B, van Loon J, Goffin J, Prósper F, Carmeliet P, García-Verdugo JM, Janssens S, Peñuelas I, Aranguren XL, Luttun A (2015). "Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake". Circulation. 131 (9): 815–26. doi:10.1161/CIRCULATIONAHA.114.013721. PMID 25561514.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.