Propionil-KoA karboksilaza
| Propionil-KoA karboksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 6.4.1.3 | ||||||||
| CAS broj | 9023-94-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Propionil-KoA karboksilaza (EC 6.4.1.3, propionil koenzim A karboksilaza) je enzim sa sistematskim imenom propanoil-KoA:ugljen-dioksid ligaza (formira ADP).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + propanoil-KoA + HCO3- ADP + fosfat + (S)-metilmalonil-KoA
Ovaj biotinilni protein takođe katalizuje karboksiciju.
Reference
- ↑ Kaziro, Y., Ochoa, S., Warner, R.C. and Chen, J.-Y. (1961). „Metabolism of propionic acid in animal tissues. VIII. Crystalline propionyl carboxylase”. J. Biol. Chem. 236: 1917-1923. PMID 13752080.
- ↑ Lane, M.D., Halenz, D.R., Kosow, D.P. and Hegre, C.S. (1960). „Further studies on mitochondrial propionyl carboxylase”. J. Biol. Chem. 235: 3082-3086. PMID 13758723.
- ↑ Meyer, H., Nevaldine, B. and Meyer, F. (1978). „Acyl-coenzyme A carboxylase of the free-living nematode Turbatrix aceti. 1. Its isolation and molecular characteristics”. Biochemistry 17: 1822-1827. PMID 656363.
- ↑ Moss, J. and Lane, M.D. (1971). „The biotin-dependent enzymes”. Adv. Enzymol. Relat. Areas Mol. Biol. 35: 321-442. PMID 4150153.
- ↑ Vagelos, P. (1971). „Regulation of fatty acid biosynthesis”. Curr. Top. Cell. Regul. 4: 119-166.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Propionyl-CoA+carboxylase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
