| MH2 domain-containing protein |
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| Identifiers |
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| Organism | Caenorhabditis elegans |
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| Symbol | daf-14 |
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| Entrez | 177908 |
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| RefSeq (mRNA) | NM_001268546.3 |
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| RefSeq (Prot) | NP_001255475.1 |
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| UniProt | G5EEP2 |
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| Other data |
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| Chromosome | IV: 10.25 - 10.26 Mb |
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| Search for |
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| Structures | Swiss-model |
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| Domains | InterPro |
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The DAF-14 is a gene of the nematode Caenorhabditis elegans encoding a R-SMAD protein of TGF-beta signaling pathway, which will be phosphorylated and forms a heterodimer with phosphorylated daf-8 when the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4, then the heterodimer enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.[1]
References
- ^ Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1–34. doi:10.1895/wormbook.1.22.2. PMC 5081272. PMID 23908056.
| Dauer Formation Abnormal protein | |
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| Downstream Of Daf protein | - Dod-3
- Dod-6
- Dod-13
- Dod-17
- Dod-18
- Dod-19
- Dod-20
- Dod-21
- Dod-22
- Dod-23
- Dod-24
|
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| Daf-12-interacting protein | |
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