Cantuzumab ravtansine
Chemical compound
NY (what is this?) (verify) Cantuzumab ravtansine (huC242-SPDB-DM4) is an antibody-drug conjugate designed for the treatment of cancers. The humanized monoclonal antibody cantuzumab (huC242) is linked to a cytotoxic agent, ravtansine (DM4).[1] It uses a more hindered disulfide linkage than cantuzumab mertansine.[2]
See also
- Cantuzumab mertansine
- ImmunoGen Inc, developer of DM4 based drugs
References
- ^ World Health Organization (2011). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 105" (PDF). WHO Drug Information. 25 (2). Archived from the original (PDF) on April 1, 2012.
- ^ Goldmacher VS, Singh R, Chittenden T, Kovtun Y (2013). "Linker technology and impact of linker design on ADC properties.". In Phillips GL (ed.). Antibody-Drug Conjugates and Immunotoxins: From Pre-Clinical Development to Therapeutic Applications. New York: Springer. pp. 117–135 (131). ISBN 978-1-4614-5456-4.
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Monoclonal antibodies for tumors
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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