OR2A4

Protein-coding gene in the species Homo sapiens
OR2A4
Identifiers
AliasesOR2A4, OR2A10, olfactory receptor family 2 subfamily A member 4, OR2A7
External IDsMGI: 104812; HomoloGene: 27232; GeneCards: OR2A4; OMA:OR2A4 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for OR2A4
Genomic location for OR2A4
Band6q23.2Start131,699,644 bp[1]
End131,701,401 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for OR2A4
Genomic location for OR2A4
Band6|6 B2.1Start43,149,074 bp[2]
End43,154,394 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of colon

  • mucosa of transverse colon

  • bone marrow cells

  • ventricular zone

  • right coronary artery

  • endometrium

  • ganglionic eminence

  • placenta

  • liver

  • muscle tissue
Top expressed in
  • testicle

  • spermatid
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • transmembrane signaling receptor activity
  • signal transducer activity
  • molecular function
Cellular component
  • integral component of membrane
  • recycling endosome
  • mitotic spindle midzone
  • mitotic spindle pole
  • plasma membrane
  • cleavage furrow
  • membrane
  • Flemming body
Biological process
  • positive regulation of cytokinesis
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • regulation of actin cytoskeleton organization
  • detection of chemical stimulus involved in sensory perception
  • signal transduction
  • response to stimulus
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79541

18310

Ensembl

ENSG00000180658

ENSMUSG00000043605

UniProt

O95047

P34984

RefSeq (mRNA)

NM_030908

NM_146652

RefSeq (protein)

NP_112170

NP_666863

Location (UCSC)Chr 6: 131.7 – 131.7 MbChr 6: 43.15 – 43.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2A4 is a protein that in humans is encoded by the OR2A4 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180658 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043605 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR2A4 olfactory receptor, family 2, subfamily A, member 4".

Further reading

  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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