Protein-coding gene in the species Homo sapiens
CEBPD |
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Identifiers |
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Aliases | CEBPD, C/EBP-delta, CELF, CRP3, NF-IL6-beta, CCAAT/enhancer binding protein delta, CCAAT enhancer binding protein delta |
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External IDs | OMIM: 116898; MGI: 103573; HomoloGene: 3808; GeneCards: CEBPD; OMA:CEBPD - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 8 (human)[1] |
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| Band | 8q11.21 | Start | 47,736,913 bp[1] |
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End | 47,738,164 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 16 (mouse)[2] |
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| Band | 16 A2|16 10.09 cM | Start | 15,705,150 bp[2] |
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End | 15,708,895 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - pericardium
- vena cava
- lower lobe of lung
- trachea
- cardia
- beta cell
- mucosa of paranasal sinus
- olfactory bulb
- cartilage tissue
- gastric mucosa
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| Top expressed in | - left lung lobe
- granulocyte
- belly cord
- endothelial cell of lymphatic vessel
- gastrula
- right lung
- muscle of thigh
- carotid body
- ankle
- ankle joint
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - DNA-binding transcription factor activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- DNA binding
- sequence-specific DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- protein binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- protein homodimerization activity
- protein heterodimerization activity
| Cellular component | | Biological process | - regulation of transcription, DNA-templated
- transcription, DNA-templated
- positive regulation of transcription by RNA polymerase II
- transcription by RNA polymerase II
- cytokine-mediated signaling pathway
- hematopoietic progenitor cell differentiation
- regulation of transcription by RNA polymerase II
- fat cell differentiation
- positive regulation of osteoblast differentiation
- negative regulation of transcription, DNA-templated
- inner ear development
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 8: 47.74 – 47.74 Mb | Chr 16: 15.71 – 15.71 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[5][6]
Function
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[7]
Functions
CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.[8]
One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.[9]
Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.[10]
Interactions
CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[11]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000221869 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071637 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Cao Z, Umek RM, McKnight SL (September 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538–1552. doi:10.1101/gad.5.9.1538. PMID 1840554.
- ^ Williams SC, Cantwell CA, Johnson PF (September 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development. 5 (9): 1553–1567. doi:10.1101/gad.5.9.1553. PMID 1884998.
- ^ "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta".
- ^ Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP (February 2005). "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene. 24 (9): 1589–1597. doi:10.1038/sj.onc.1208393. PMID 15674331. S2CID 24347537.
- ^ Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA (January 2014). "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (1): 89–97. doi:10.1038/labinvest.2013.127. PMID 24247561.
- ^ Munkácsy G, Sztupinszki Z, Herman P, Bán B, Pénzváltó Z, Szarvas N, et al. (September 2016). "Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments". Molecular Therapy. Nucleic Acids. 5 (9): e366. doi:10.1038/mtna.2016.66. PMC 5056990. PMID 27673562.
- ^ Choy L, Derynck R (March 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". The Journal of Biological Chemistry. 278 (11): 9609–9619. doi:10.1074/jbc.M212259200. PMID 12524424.
Further reading
- Sladek FM, Darnell JE (April 1992). "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development. 2 (2): 256–259. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.
- Kinoshita S, Akira S, Kishimoto T (February 1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6". Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1473–1476. Bibcode:1992PNAS...89.1473K. doi:10.1073/pnas.89.4.1473. PMC 48473. PMID 1741402.
- Nagulapalli S, Pongubala JM, Atchison ML (November 1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)". Journal of Immunology. 155 (9): 4330–4338. doi:10.4049/jimmunol.155.9.4330. PMID 7594592.
- Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p". Cytogenetics and Cell Genetics. 70 (3–4): 188–191. doi:10.1159/000134030. PMID 7789168.
- Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, et al. (May 1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization". Genomics. 16 (2): 520–523. doi:10.1006/geno.1993.1220. PMID 8314590.
- Chen PL, Riley DJ, Chen Y, Lee WH (November 1996). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs". Genes & Development. 10 (21): 2794–2804. doi:10.1101/gad.10.21.2794. PMID 8946919.
- Xia C, Cheshire JK, Patel H, Woo P (December 1997). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". The International Journal of Biochemistry & Cell Biology. 29 (12): 1525–1539. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146.
- Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK (March 2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins". The Journal of Biological Chemistry. 277 (9): 6923–6928. doi:10.1074/jbc.M108075200. PMID 11741938.
- Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, et al. (December 2001). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2". Molecular and Cellular Probes. 15 (6): 395–397. doi:10.1006/mcpr.2001.0377. hdl:11382/3170. PMID 11851384. S2CID 8215328.
- Gao H, Parkin S, Johnson PF, Schwartz RC (October 2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". The Journal of Biological Chemistry. 277 (41): 38827–38837. doi:10.1074/jbc.M206224200. PMID 12177065.
- Dearth LR, DeWille J (March 2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells". The Journal of Biological Chemistry. 278 (13): 11246–11255. doi:10.1074/jbc.M207930200. PMID 12554732.
- Milde-Langosch K, Löning T, Bamberger AM (May 2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins". Breast Cancer Research and Treatment. 79 (2): 175–185. doi:10.1023/A:1023929504884. PMID 12825852. S2CID 45020949.
- Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR (September 2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". The Journal of Biological Chemistry. 278 (38): 36959–36965. doi:10.1074/jbc.M303147200. PMID 12857754.
- Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM (December 2003). "Molecular responses of human muscle to eccentric exercise". Journal of Applied Physiology. 95 (6): 2485–2494. doi:10.1152/japplphysiol.01161.2002. PMID 12937035. S2CID 9817319.
- Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J (September 2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease". Neurobiology of Aging. 25 (8): 991–999. doi:10.1016/j.neurobiolaging.2003.10.016. PMID 15212823. S2CID 54232508.
- Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW (November 2004). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control". Journal of Cellular Biochemistry. 93 (4): 844–856. doi:10.1002/jcb.20224. PMID 15389878. S2CID 31572695.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
(1) Basic domains |
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(1.1) Basic leucine zipper (bZIP) | |
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(1.2) Basic helix-loop-helix (bHLH) | Group A | |
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Group B | |
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Group C bHLH-PAS | |
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Group D | |
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Group E | |
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Group F bHLH-COE | |
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(1.3) bHLH-ZIP | |
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(1.4) NF-1 | |
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(1.5) RF-X | |
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(1.6) Basic helix-span-helix (bHSH) | |
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(2) Zinc finger DNA-binding domains |
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(2.1) Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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see also transcription factor/coregulator deficiencies |
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