ZEB1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | ZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A |
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External IDs | OMIM: 189909; MGI: 1344313; HomoloGene: 31779; GeneCards: ZEB1; OMA:ZEB1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 10 (human)[1] |
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| Band | 10p11.22 | Start | 31,318,495 bp[1] |
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End | 31,529,814 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 18 (mouse)[2] |
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| Band | 18 4.42 cM|18 A1 | Start | 5,591,860 bp[2] |
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End | 5,775,467 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Achilles tendon
- epithelium of colon
- decidua
- optic nerve
- glutes
- endothelial cell
- Skeletal muscle tissue of rectus abdominis
- biceps brachii
- tendon of biceps brachii
- Skeletal muscle tissue of biceps brachii
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| Top expressed in | - internal carotid artery
- substantia nigra
- motor neuron
- external carotid artery
- semi-lunar valve
- carotid body
- ascending aorta
- Rostral migratory stream
- suprachiasmatic nucleus
- Gonadal ridge
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - DNA binding
- transcription corepressor activity
- transcription coactivator activity
- zinc ion binding
- transcription factor binding
- chromatin binding
- metal ion binding
- protein binding
- nucleic acid binding
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- E-box binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Cellular component | - transcription regulator complex
- nucleus
- nucleoplasm
- cytosol
| Biological process | - pattern specification process
- embryonic skeletal system morphogenesis
- regulation of smooth muscle cell differentiation
- animal organ development
- cell differentiation
- semicircular canal morphogenesis
- regulation of transcription, DNA-templated
- regulation of transcription by RNA polymerase II
- transcription, DNA-templated
- nervous system development
- regulation of transforming growth factor beta receptor signaling pathway
- regulation of T cell differentiation in thymus
- central nervous system development
- cartilage development
- regulation of mesenchymal cell proliferation
- embryonic camera-type eye morphogenesis
- cochlea morphogenesis
- immune response
- embryonic morphogenesis
- cellular response to amino acid stimulus
- cell population proliferation
- negative regulation of epithelial cell differentiation
- positive regulation of transcription by RNA polymerase II
- negative regulation of cell population proliferation
- negative regulation of transcription, DNA-templated
- positive regulation of neuron differentiation
- negative regulation of transcription by RNA polymerase II
- negative regulation of endothelial cell differentiation
- cytokine-mediated signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001128128 NM_001174093 NM_001174094 NM_001174095 NM_001174096
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NM_030751 NM_001323638 NM_001323641 NM_001323642 NM_001323643 NM_001323644 NM_001323645 NM_001323646 NM_001323647 NM_001323648 NM_001323649 NM_001323650 NM_001323651 NM_001323652 NM_001323653 NM_001323654 NM_001323655 NM_001323656 NM_001323657 NM_001323658 NM_001323659 NM_001323660 NM_001323661 NM_001323662 NM_001323663 NM_001323664 NM_001323665 NM_001323666 NM_001323671 NM_001323672 NM_001323673 NM_001323674 NM_001323675 NM_001323676 NM_001323677 NM_001323678 |
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NM_011546 NM_001360981 NM_001360982 |
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RefSeq (protein) | NP_001121600 NP_001167564 NP_001167565 NP_001167566 NP_001167567
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NP_001310567 NP_001310570 NP_001310571 NP_001310572 NP_001310573 NP_001310574 NP_001310575 NP_001310576 NP_001310577 NP_001310578 NP_001310579 NP_001310580 NP_001310581 NP_001310582 NP_001310583 NP_001310584 NP_001310585 NP_001310586 NP_001310587 NP_001310588 NP_001310589 NP_001310590 NP_001310591 NP_001310592 NP_001310593 NP_001310594 NP_001310595 NP_001310600 NP_001310601 NP_001310602 NP_001310603 NP_001310604 NP_001310605 NP_001310606 NP_001310607 NP_110378 |
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NP_035676 NP_001347910 NP_001347911 |
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Location (UCSC) | Chr 10: 31.32 – 31.53 Mb | Chr 18: 5.59 – 5.78 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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