HEY1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | HEY1, BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1, hes related family bHLH transcription factor with YRPW motif 1, NERP2 |
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External IDs | OMIM: 602953; MGI: 1341800; HomoloGene: 7756; GeneCards: HEY1; OMA:HEY1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 8 (human)[1] |
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| Band | 8q21.13 | Start | 79,762,371 bp[1] |
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End | 79,767,857 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 3 (mouse)[2] |
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| Band | 3 A1|3 2.15 cM | Start | 8,728,419 bp[2] |
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End | 8,732,316 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - endothelial cell
- Brodmann area 23
- optic nerve
- middle temporal gyrus
- dorsal motor nucleus of vagus nerve
- spinal ganglia
- trigeminal ganglion
- internal globus pallidus
- visceral pleura
- mucosa of paranasal sinus
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| Top expressed in | - pharyngeal groove
- molar
- ventricular zone
- aortic valve
- right lung lobe
- nasal epithelium
- olfactory epithelium
- renal corpuscle
- tail of embryo
- left lung
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - microsatellite binding
- DNA binding
- protein dimerization activity
- DNA-binding transcription factor activity
- transcription factor binding
- RNA polymerase II general transcription initiation factor activity
- protein binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- transcription corepressor activity
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
| Cellular component | - cytoplasm
- nucleoplasm
- nucleus
| Biological process | - dorsal aorta morphogenesis
- pulmonary valve morphogenesis
- negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
- regulation of transcription, DNA-templated
- heart trabecula formation
- regulation of vasculogenesis
- cardiac septum morphogenesis
- ventricular septum morphogenesis
- labyrinthine layer blood vessel development
- negative regulation of transcription by RNA polymerase II
- transcription, DNA-templated
- endocardial cushion morphogenesis
- multicellular organism development
- atrioventricular valve formation
- arterial endothelial cell differentiation
- cellular response to glucocorticoid stimulus
- umbilical cord morphogenesis
- negative regulation of transcription regulatory region DNA binding
- angiogenesis
- negative regulation of transcription, DNA-templated
- cardiac ventricle morphogenesis
- positive regulation of transcription by RNA polymerase II
- negative regulation of Notch signaling pathway
- cardiac epithelial to mesenchymal transition
- Notch signaling involved in heart development
- Notch signaling pathway
- positive regulation of transcription, DNA-templated
- blood vessel development
- heart development
- cell differentiation
- regulation of neurogenesis
- positive regulation of gene expression
- negative regulation of biomineral tissue development
- anterior/posterior pattern specification
- negative regulation of neuron differentiation
- circulatory system development
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_012258 NM_001040708 NM_001282851 |
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RefSeq (protein) | |
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NP_001035798 NP_001269780 NP_036390 |
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Location (UCSC) | Chr 8: 79.76 – 79.77 Mb | Chr 3: 8.73 – 8.73 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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