Mammalian protein found in Homo sapiens
TOX high mobility group box family member 2 |
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Identifiers |
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Symbol | TOX2 |
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Alt. symbols | C20orf100, GCX-1 |
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NCBI gene | 84969 |
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HGNC | 16095 |
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OMIM | 611163 |
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RefSeq | NM_001098796 |
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UniProt | Q96NM4 |
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Other data |
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Locus | Chr. 20 q13.12 |
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Search for |
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Structures | Swiss-model |
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Domains | InterPro |
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TOX high mobility group box family member 2, also known as TOX2, is a human gene.[1][2]
The protein encoded by this gene is a member of a subfamily of transcription factors that also includes TOX, TOX3, and TOX4 that share almost identical HMG-box DNA-binding domains which function to modify chromatin structure.[3]
References
- ^ "Entrez Gene: TOX high mobility group box family member 2".
- ^ Kajitani T, Mizutani T, Yamada K, Yazawa T, Sekiguchi T, Yoshino M, Kawata H, Miyamoto K (May 2004). "Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells". Endocrinology. 145 (5): 2307–18. doi:10.1210/en.2003-1343. PMID 14764631. S2CID 25037508.
- ^ O'Flaherty E, Kaye J (April 2003). "TOX defines a conserved subfamily of HMG-box proteins". BMC Genomics. 4 (1): 13. doi:10.1186/1471-2164-4-13. PMC 155677. PMID 12697058.
Transcription factors and intracellular receptors
(1) Basic domains |
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(1.1) Basic leucine zipper (bZIP) | |
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(1.2) Basic helix-loop-helix (bHLH) | Group A | |
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Group B | |
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Group C bHLH-PAS | |
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Group D | |
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Group E | |
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Group F bHLH-COE | |
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(1.3) bHLH-ZIP | |
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(1.4) NF-1 | |
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(1.5) RF-X | |
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(1.6) Basic helix-span-helix (bHSH) | |
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(2) Zinc finger DNA-binding domains |
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(2.1) Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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see also transcription factor/coregulator deficiencies |
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