MEOX2

Protein-coding gene in the species Homo sapiens

MEOX2
Identifiers
AliasesMEOX2, GAX, MOX2, mesenchyme homeobox 2
External IDsOMIM: 600535; MGI: 103219; HomoloGene: 4330; GeneCards: MEOX2; OMA:MEOX2 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for MEOX2
Genomic location for MEOX2
Band7p21.2Start15,611,212 bp[1]
End15,686,683 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for MEOX2
Genomic location for MEOX2
Band12 A3|12 16.84 cMStart37,158,539 bp[2]
End37,229,533 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • parietal pleura

  • spinal ganglia

  • tibial nerve

  • synovial joint

  • subcutaneous adipose tissue

  • tendon of biceps brachii

  • saphenous vein

  • sural nerve

  • trigeminal ganglion
Top expressed in
  • left lung lobe

  • sciatic nerve

  • lumbar spinal ganglion

  • dermis

  • hand

  • foot

  • ankle

  • human fetus

  • carotid body

  • limb bud
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • sequence-specific DNA binding
  • DNA binding
  • DNA-binding transcription factor activity
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • cytoplasm
  • nuclear speck
  • nucleus
Biological process
  • neuron death
  • roof of mouth development
  • regulation of transcription, DNA-templated
  • somite specification
  • blood circulation
  • transcription, DNA-templated
  • limb development
  • multicellular organism development
  • angiogenesis
  • skeletal muscle tissue development
  • positive regulation of transcription by RNA polymerase II
  • negative regulation of cell migration involved in sprouting angiogenesis
  • transcription by RNA polymerase II
  • somite development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4223

17286

Ensembl

ENSG00000106511

ENSMUSG00000036144

UniProt

P50222

P32443

RefSeq (mRNA)

NM_005924

NM_008584

RefSeq (protein)

NP_005915

NP_032610

Location (UCSC)Chr 7: 15.61 – 15.69 MbChr 12: 37.16 – 37.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.[5][6]

Function

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[6] MEOX2 has been implicated in the initiation of tumors in glioma.[7] Additionally, MEOX2 influences several critical processes in lung cancer, including cellular proliferation, invasion, metastasis, angiogenesis, and the development of drug resistance.[8][9]

Interactions

MEOX2 has been shown to interact with PAX1[10] and PAX3.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106511 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036144 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ LePage DF, Altomare DA, Testa JR, Walsh K (December 1994). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics. 24 (3): 535–540. doi:10.1006/geno.1994.1663. PMID 7713505.
  6. ^ a b "Entrez Gene: MEOX2 mesenchyme homeobox 2".
  7. ^ Wang J, Chen Y, Wang Q, Xu H, Wu C, Jiang Q, et al. (April 2022). "MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma". Cell Death & Disease. 13 (4): 360. doi:10.1038/s41419-022-04845-2. PMC 9016080. PMID 35436995.
  8. ^ Armas-López L, Piña-Sánchez P, Arrieta O, de Alba EG, Ortiz-Quintero B, Santillán-Doherty P, et al. (September 2017). "Epigenomic study identifies a novel mesenchyme homeobox2-GLI1 transcription axis involved in cancer drug resistance, overall survival and therapy prognosis in lung cancer patients". Oncotarget. 8 (40): 67056–67081. doi:10.18632/oncotarget.17715. PMC 5620156. PMID 28978016.
  9. ^ Peralta-Arrieta I, Trejo-Villegas OA, Armas-López L, Ceja-Rangel HA, Ordóñez-Luna MD, Pineda-Villegas P, et al. (January 2022). "Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer". European Journal of Cancer. 160: 189–205. doi:10.1016/j.ejca.2021.10.032. PMID 34844838.
  10. ^ a b Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (June 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Letters. 499 (3): 274–278. Bibcode:2001FEBSL.499..274S. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.

Further reading

  • Grigoriou M, Kastrinaki MC, Modi WS, Theodorakis K, Mankoo B, Pachnis V, et al. (April 1995). "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3". Genomics. 26 (3): 550–555. doi:10.1016/0888-7543(95)80174-K. PMID 7607679.
  • Reardon W, McManus SP, Summers D, Winter RM (October 1993). "Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2". American Journal of Medical Genetics. 47 (5): 633–636. doi:10.1002/ajmg.1320470510. PMID 8266988.
  • Quinn LM, Latham SE, Kalionis B (2000). "The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta". Placenta. 21 Suppl A: S50–S54. doi:10.1053/plac.1999.0514. PMID 10831122.
  • Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (June 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Letters. 499 (3): 274–278. Bibcode:2001FEBSL.499..274S. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.
  • Gorski DH, Leal AJ (May 2003). "Inhibition of endothelial cell activation by the homeobox gene Gax". The Journal of Surgical Research. 111 (1): 91–99. doi:10.1016/S0022-4804(03)00042-8. PMID 12842453.
  • Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, et al. (September 2005). "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease". Nature Medicine. 11 (9): 959–965. doi:10.1038/nm1287. PMID 16116430. S2CID 12998034.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Lin J, Friesen MT, Bocangel P, Cheung D, Rawszer K, Wigle JT (July 2005). "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10". Molecular and Cellular Biochemistry. 275 (1–2): 75–84. doi:10.1007/s11010-005-0823-3. PMID 16335786. S2CID 30515981.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Chen Y, Leal AD, Patel S, Gorski DH (January 2007). "The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences". The Journal of Biological Chemistry. 282 (1): 507–517. doi:10.1074/jbc.M606604200. PMC 1865102. PMID 17074759.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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