Protein-coding gene in the species Homo sapiens
DBX1 |
---|
|
Identifiers |
---|
Aliases | DBX1, developing brain homeobox 1, HLX1 |
---|
External IDs | MGI: 94867; HomoloGene: 19002; GeneCards: DBX1; OMA:DBX1 - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 11 (human)[1] |
---|
| Band | 11p15.1 | Start | 20,156,155 bp[1] |
---|
End | 20,160,475 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 7 (mouse)[2] |
---|
| Band | 7 B4|7 31.44 cM | Start | 49,281,247 bp[2] |
---|
End | 49,286,597 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - gonad
- pituitary gland
- right testis
- left testis
|
| Top expressed in | - embryo
- tongue
- pineal gland
- embryo
- desmocranium
- condyle
- ventricular zone
- dermis
- Basal plate
- extraocular muscle
|
| More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | - sequence-specific DNA binding
- DNA binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Cellular component | | Biological process | - regulation of transcription by RNA polymerase II
- multicellular organism development
- ventral spinal cord interneuron specification
- regulation of transcription, DNA-templated
- cell differentiation in spinal cord
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq (protein) | | |
---|
Location (UCSC) | Chr 11: 20.16 – 20.16 Mb | Chr 7: 49.28 – 49.29 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|
Homeobox protein DBX1, also known as developing brain homeobox protein 1, is a protein that in humans is encoded by the DBX1 gene. The DBX1 gene is a transcription factor gene that is pivotal in interneuron differentiation in the ventral spinal cord.
The spinal interneurons V0 and V1 are derived from progenitor domains that are differentiated by the expression of homeodomain proteins DBX1 and DBX2. DBX1 is spatially restricted and has a critical role in establishing the distinction of V0 and V1 neuronal fate. In DBX1 mutant mice, neural progenitors fail to generate V0 interneurons and instead gave rise to interneurons expressing V1 characteristics, such as their transcription factor profile, neurotransmitter phenotype, migratory pattern, and aspects of their axonal trajectory, suggesting that this single homeodomain transcription factor coordinates many of the differentiated properties of one class of interneurons generated in the ventral spinal cord.
V0 and V1 interneurons are thought to be critical in the role of rhythmic breathing, after using a neonatal mouse model. Destruction of these DBX1 neurons in the pre-Botzinger complex showed an impaired respiratory rhythm as well as a decreased magnitude of motor output activity.[5][6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000109851 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030507 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: developing brain homeobox 1".
- ^ Pierani A, Moran-Rivard L, Sunshine MJ, Littman DR, Goulding M, Jessell TM (February 2001). "Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1". Neuron. 29 (2): 367–84. doi:10.1016/S0896-6273(01)00212-4. PMID 11239429. S2CID 2647092.
(1) Basic domains |
---|
(1.1) Basic leucine zipper (bZIP) | |
---|
(1.2) Basic helix-loop-helix (bHLH) | Group A | |
---|
Group B | |
---|
Group C bHLH-PAS | |
---|
Group D | |
---|
Group E | |
---|
Group F bHLH-COE | |
---|
|
---|
(1.3) bHLH-ZIP | |
---|
(1.4) NF-1 | |
---|
(1.5) RF-X | |
---|
(1.6) Basic helix-span-helix (bHSH) | |
---|
|
|
(2) Zinc finger DNA-binding domains |
---|
(2.1) Nuclear receptor (Cys4) | subfamily 1 | |
---|
subfamily 2 | |
---|
subfamily 3 | |
---|
subfamily 4 | |
---|
subfamily 5 | |
---|
subfamily 6 | |
---|
subfamily 0 | |
---|
|
---|
(2.2) Other Cys4 | |
---|
(2.3) Cys2His2 | |
---|
(2.4) Cys6 | |
---|
(2.5) Alternating composition | |
---|
(2.6) WRKY | |
---|
|
|
|
(4) β-Scaffold factors with minor groove contacts |
---|
|
|
(0) Other transcription factors |
---|
|
|
see also transcription factor/coregulator deficiencies |
| This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it. |