TFAP4 |
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Identifiers |
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Aliases | TFAP4, AP-4, bHLHc41, transcription factor AP-4 (activating enhancer binding protein 4), transcription factor AP-4 |
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External IDs | OMIM: 600743; MGI: 103239; HomoloGene: 2424; GeneCards: TFAP4; OMA:TFAP4 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 16 (human)[1] |
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| Band | 16p13.3 | Start | 4,257,186 bp[1] |
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End | 4,273,075 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 16 (mouse)[2] |
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| Band | 16 A1|16 2.45 cM | Start | 4,362,525 bp[2] |
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End | 4,377,718 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - olfactory bulb
- beta cell
- vena cava
- sural nerve
- ganglionic eminence
- cerebellar hemisphere
- lateral nuclear group of thalamus
- subthalamic nucleus
- nasal epithelium
- right hemisphere of cerebellum
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| Top expressed in | - tail of embryo
- genital tubercle
- ventricular zone
- yolk sac
- epiblast
- female urethra
- muscle of thigh
- lip
- zygote
- embryo
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - sequence-specific DNA binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- protein homodimerization activity
- protein dimerization activity
- transcription coactivator activity
- histone deacetylase binding
- protein heterodimerization activity
- transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- protein binding
- DNA binding
- E-box binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
| Cellular component | - transcription repressor complex
- nucleus
- mitochondrion
| Biological process | - negative regulation of cell population proliferation
- negative regulation of cyclin-dependent protein serine/threonine kinase activity
- transcription, DNA-templated
- negative regulation of gene expression
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- cellular response to dexamethasone stimulus
- negative regulation of DNA binding
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- positive regulation of apoptotic process
- positive regulation of transcription, DNA-templated
- regulation of transcription, DNA-templated
- positive regulation of transcription by RNA polymerase II
- transcription by RNA polymerase II
- negative regulation of transcription, DNA-templated
- regulation of mitotic cell cycle phase transition
- protein-containing complex assembly
- regulation of transcription by RNA polymerase II
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 16: 4.26 – 4.27 Mb | Chr 16: 4.36 – 4.38 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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