Protein-coding gene in the species Homo sapiens
ZNF19 |
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Identifiers |
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Aliases | ZNF19, KOX12, zinc finger protein 19 |
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External IDs | OMIM: 194525; HomoloGene: 56009; GeneCards: ZNF19; OMA:ZNF19 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 16 (human)[1] |
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| Band | 16q22.2 | Start | 71,464,555 bp[1] |
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End | 71,565,089 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right uterine tube
- mucosa of ileum
- pancreatic ductal cell
- tibialis anterior muscle
- right testis
- left testis
- gonad
- anterior pituitary
- right lobe of thyroid gland
- left lobe of thyroid gland
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| | More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - DNA-binding transcription factor activity
- DNA binding
- metal ion binding
- nucleic acid binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Cellular component | - intracellular anatomical structure
- nucleus
| Biological process | - regulation of transcription, DNA-templated
- transcription, DNA-templated
- regulation of transcription by RNA polymerase II
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 16: 71.46 – 71.57 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Zinc finger protein 19 is a protein that in humans is encoded by the ZNF19 gene.[3][4][5]
The protein encoded by this gene contains a zinc finger, a nucleic acid-binding domain present in many transcription factors. This gene is located in a region next to ZNF23, a gene also encoding a zinc finger protein, on chromosome 16.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000157429 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lichter P, Bray P, Ried T, Dawid IB, Ward DC (Sep 1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 (4): 999–1007. doi:10.1016/0888-7543(92)90013-I. PMID 1505991.
- ^ Bray P, Lichter P, Thiesen HJ, Ward DC, Dawid IB (Dec 1991). "Characterization and mapping of human genes encoding zinc finger proteins". Proc Natl Acad Sci U S A. 88 (21): 9563–7. Bibcode:1991PNAS...88.9563B. doi:10.1073/pnas.88.21.9563. PMC 52758. PMID 1946370.
- ^ a b "Entrez Gene: ZNF19 zinc finger protein 19".
Further reading
- Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–74. PMID 2288909.
- Tommerup N, Vissing H (1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders". Genomics. 27 (2): 259–64. doi:10.1006/geno.1995.1040. PMID 7557990.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
(1) Basic domains |
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(1.1) Basic leucine zipper (bZIP) | |
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(1.2) Basic helix-loop-helix (bHLH) | Group A | |
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Group B | |
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Group C bHLH-PAS | |
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Group D | |
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Group E | |
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Group F bHLH-COE | |
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(1.3) bHLH-ZIP | |
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(1.4) NF-1 | |
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(1.5) RF-X | |
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(1.6) Basic helix-span-helix (bHSH) | |
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(2) Zinc finger DNA-binding domains |
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(2.1) Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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see also transcription factor/coregulator deficiencies |
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