Protein-coding gene in the species Homo sapiens
ZNF41 |
---|
|
Identifiers |
---|
Aliases | ZNF41, MRX89, zinc finger protein 41 |
---|
External IDs | OMIM: 314995; HomoloGene: 133263; GeneCards: ZNF41; OMA:ZNF41 - orthologs |
---|
Gene location (Human) |
---|
| Chr. | X chromosome (human)[1] |
---|
| Band | Xp11.3 | Start | 47,445,178 bp[1] |
---|
End | 47,483,222 bp[1] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - muscle of leg
- gonad
- gastrocnemius muscle
- muscle of thigh
- islet of Langerhans
- apex of heart
- rectum
- ganglionic eminence
- ventricular zone
- white blood cell
|
| | More reference expression data |
|
---|
BioGPS | | More reference expression data |
|
---|
|
Gene ontology |
---|
Molecular function | - DNA-binding transcription factor activity
- DNA binding
- protein binding
- metal ion binding
- nucleic acid binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Cellular component | - intracellular anatomical structure
- nucleus
| Biological process | - regulation of transcription, DNA-templated
- transcription, DNA-templated
- regulation of transcription by RNA polymerase II
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | NM_007130 NM_153380 NM_001324139 NM_001324140 NM_001324141
|
---|
NM_001324142 NM_001324143 NM_001324144 NM_001324145 NM_001324147 NM_001324148 NM_001324149 NM_001324150 NM_001324151 NM_001324152 NM_001324153 NM_001324154 NM_001324155 NM_001324156 NM_001324157 |
| |
---|
RefSeq (protein) | NP_001311068 NP_001311069 NP_001311070 NP_001311071 NP_001311072
|
---|
NP_001311073 NP_001311074 NP_001311076 NP_001311077 NP_001311078 NP_001311079 NP_001311080 NP_001311081 NP_001311082 NP_001311083 NP_001311084 NP_001311085 NP_001311086 NP_009061 NP_700359 |
| |
---|
Location (UCSC) | Chr X: 47.45 – 47.48 Mb | n/a |
---|
PubMed search | [2] | n/a |
---|
|
Wikidata |
|
Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene.[3][4]
This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. Several alternatively spliced transcript variants have been described, however, the full-length nature of only some of them is known.[4]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000147124 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Franze A, Archidiacono N, Rocchi M, Marino M, Grimaldi G (Jul 1991). "Isolation and expression analysis of a human zinc finger gene (ZNF41) located on the short arm of the X chromosome". Genomics. 9 (4): 728–36. doi:10.1016/0888-7543(91)90367-N. PMID 2037297.
- ^ a b "Entrez Gene: ZNF41 zinc finger protein 41".
Further reading
- Rosati M, Marino M, Franzè A, et al. (1991). "Members of the zinc finger protein gene family sharing a conserved N-terminal module". Nucleic Acids Res. 19 (20): 5661–7. doi:10.1093/nar/19.20.5661. PMC 328972. PMID 1945843.
- Knight JC, Grimaldi G, Thiesen HJ, et al. (1994). "Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1". Genomics. 21 (1): 180–7. doi:10.1006/geno.1994.1240. PMID 8088786.
- Rosati M, Franzé A, Matarazzo MR, Grimaldi G (1999). "Coding region intron/exon organization, alternative splicing, and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41". Cytogenet. Cell Genet. 85 (3–4): 291–6. doi:10.1159/000015315 (inactive 2024-07-25). PMID 10449920. S2CID 26777065.
{{cite journal}}
: CS1 maint: DOI inactive as of July 2024 (link) - Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Shoichet SA, Hoffmann K, Menzel C, et al. (2004). "Mutations in the ZNF41 gene are associated with cognitive deficits: identification of a new candidate for X-linked mental retardation". Am. J. Hum. Genet. 73 (6): 1341–54. doi:10.1086/380309. PMC 1180399. PMID 14628291.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
(1) Basic domains |
---|
(1.1) Basic leucine zipper (bZIP) | |
---|
(1.2) Basic helix-loop-helix (bHLH) | Group A | |
---|
Group B | |
---|
Group C bHLH-PAS | |
---|
Group D | |
---|
Group E | |
---|
Group F bHLH-COE | |
---|
|
---|
(1.3) bHLH-ZIP | |
---|
(1.4) NF-1 | |
---|
(1.5) RF-X | |
---|
(1.6) Basic helix-span-helix (bHSH) | |
---|
|
|
(2) Zinc finger DNA-binding domains |
---|
(2.1) Nuclear receptor (Cys4) | subfamily 1 | |
---|
subfamily 2 | |
---|
subfamily 3 | |
---|
subfamily 4 | |
---|
subfamily 5 | |
---|
subfamily 6 | |
---|
subfamily 0 | |
---|
|
---|
(2.2) Other Cys4 | |
---|
(2.3) Cys2His2 | |
---|
(2.4) Cys6 | |
---|
(2.5) Alternating composition | |
---|
(2.6) WRKY | |
---|
|
|
|
(4) β-Scaffold factors with minor groove contacts |
---|
|
|
(0) Other transcription factors |
---|
|
|
see also transcription factor/coregulator deficiencies |
| This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it. |