ZBTB7A

Protein-coding gene in the species Homo sapiens
ZBTB7A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2IF5, 2NN2

Identifiers
AliasesZBTB7A, FBI-1, FBI1, LRF, ZBTB7, ZNF857A, pokemon, TIP21, zinc finger and BTB domain containing 7A, MNDLFH
External IDsOMIM: 605878; MGI: 1335091; HomoloGene: 7820; GeneCards: ZBTB7A; OMA:ZBTB7A - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ZBTB7A
Genomic location for ZBTB7A
Band19p13.3Start4,043,303 bp[1]
End4,066,899 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for ZBTB7A
Genomic location for ZBTB7A
Band10|10 C1Start80,971,054 bp[2]
End80,988,829 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • nipple

  • internal globus pallidus

  • middle temporal gyrus

  • pylorus

  • cerebellar vermis

  • Brodmann area 23

  • cardia

  • vulva

  • superior surface of tongue

  • ventral tegmental area
Top expressed in
  • ascending aorta

  • aortic valve

  • inner renal medulla

  • superior frontal gyrus

  • glomerulus

  • lip

  • granulocyte

  • right kidney

  • esophagus

  • cerebellar cortex
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • protein binding
  • histone acetyltransferase binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • transcription corepressor binding
  • DNA-binding transcription factor activity
  • transcription corepressor activity
  • sequence-specific DNA binding
  • SMAD binding
  • androgen receptor binding
Cellular component
  • nucleus
  • cytoplasm
  • NuRD complex
  • site of double-strand break
  • DNA-dependent protein kinase complex
Biological process
  • multicellular organism development
  • cell differentiation
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • regulation of alternative mRNA splicing, via spliceosome
  • regulation of glycolytic process
  • chromatin organization
  • chromatin remodeling
  • cellular response to DNA damage stimulus
  • B cell differentiation
  • negative regulation of transforming growth factor beta receptor signaling pathway
  • protein localization to nucleus
  • regulation of apoptotic process
  • erythrocyte maturation
  • fat cell differentiation
  • negative regulation of Notch signaling pathway
  • regulation of DNA-binding transcription factor activity
  • positive regulation of NF-kappaB transcription factor activity
  • negative regulation of androgen receptor signaling pathway
  • double-strand break repair via classical nonhomologous end joining
  • regulation of transcription regulatory region DNA binding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51341

16969

Ensembl

ENSG00000178951

ENSMUSG00000035011

UniProt

O95365

O88939

RefSeq (mRNA)

NM_015898
NM_001317990
NM_020224

NM_010731

RefSeq (protein)

NP_001304919
NP_056982

NP_034861
NP_001391790
NP_001391791
NP_001391792
NP_001391793

NP_001391794
NP_001391795
NP_001391796

Location (UCSC)Chr 19: 4.04 – 4.07 MbChr 10: 80.97 – 80.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.[5][6][7]

Interactions

ZBTB7A has been shown to interact with BCL6.[8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178951 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035011 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Morrison DJ, Pendergrast PS, Stavropoulos P, Colmenares SU, Kobayashi R, Hernandez N (Apr 1999). "FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein". Nucleic Acids Res. 27 (5): 1251–62. doi:10.1093/nar/27.5.1251. PMC 148309. PMID 9973611.
  6. ^ Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (Feb 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene. 18 (2): 365–75. doi:10.1038/sj.onc.1202332. PMID 9927193. S2CID 5769828.
  7. ^ "Entrez Gene: ZBTB7A zinc finger and BTB domain containing 7A".
  8. ^ Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (January 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene. 18 (2): 365–75. doi:10.1038/sj.onc.1202332. PMID 9927193. S2CID 5769828.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Pendergrast PS, Wang C, Hernandez N, Huang S (2002). "FBI-1 Can Stimulate HIV-1 Tat Activity and Is Targeted to a Novel Subnuclear Domain that Includes the Tat-P-TEFb—containing Nuclear Speckles". Mol. Biol. Cell. 13 (3): 915–29. doi:10.1091/mbc.01-08-0383. PMC 99609. PMID 11907272.
  • Lee DK, Suh D, Edenberg HJ, Hur MW (2002). "POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1". J. Biol. Chem. 277 (30): 26761–8. doi:10.1074/jbc.M202078200. PMID 12004059.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Pessler F, Hernandez N (2003). "Flexible DNA binding of the BTB/POZ-domain protein FBI-1". J. Biol. Chem. 278 (31): 29327–35. doi:10.1074/jbc.M302980200. PMID 12750370.
  • Laudes M, Christodoulides C, Sewter C, et al. (2004). "Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis". J. Biol. Chem. 279 (12): 11711–8. doi:10.1074/jbc.M310240200. PMC 4303998. PMID 14701838.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Liu CJ, Prazak L, Fajardo M, et al. (2004). "Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis". J. Biol. Chem. 279 (45): 47081–91. doi:10.1074/jbc.M405288200. PMID 15337766.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Maeda T, Hobbs RM, Merghoub T, et al. (2005). "Role of the proto-oncogene Pokémon in cellular transformation and ARF repression". Nature. 433 (7023): 278–85. Bibcode:2005Natur.433..278M. doi:10.1038/nature03203. PMID 15662416. S2CID 4308742.
  • Lee DK, Kang JE, Park HJ, et al. (2005). "FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB". J. Biol. Chem. 280 (30): 27783–91. doi:10.1074/jbc.M504909200. PMID 15917220.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Roh HE, Lee MN, Jeon BN, et al. (2007). "Regulation of Pokémon 1 activity by sumoylation". Cell. Physiol. Biochem. 20 (1–4): 167–80. doi:10.1159/000104164. PMID 17595526.
  • v
  • t
  • e
  • 2if5: Structure of the POZ domain of human LRF, a master regulator of oncogenesis
    2if5: Structure of the POZ domain of human LRF, a master regulator of oncogenesis
  • 2nn2: Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator
    2nn2: Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator
  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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