ZNF259

Protein-coding gene in the species Homo sapiens
ZPR1
Identifiers
AliasesZPR1, ZNF259, ZPR1 zinc finger, GKAF
External IDsOMIM: 603901; MGI: 1330262; HomoloGene: 2900; GeneCards: ZPR1; OMA:ZPR1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ZPR1
Genomic location for ZPR1
Band11q23.3Start116,773,799 bp[1]
End116,788,039 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for ZPR1
Genomic location for ZPR1
Band9|9 A5.2Start46,184,362 bp[2]
End46,193,941 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • right testis

  • sperm

  • left testis

  • islet of Langerhans

  • sural nerve

  • Achilles tendon

  • body of pancreas

  • right lobe of liver

  • smooth muscle tissue
Top expressed in
  • epiblast

  • tail of embryo

  • embryo

  • Rostral migratory stream

  • embryo

  • seminiferous tubule

  • genital tubercle

  • muscle of thigh

  • yolk sac

  • morula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • receptor tyrosine kinase binding
  • zinc ion binding
  • metal ion binding
  • protein binding
  • translation initiation factor binding
Cellular component
  • cytoplasm
  • perikaryon
  • Cajal body
  • cell projection
  • growth cone
  • nucleoplasm
  • SMN complex
  • axon
  • neuronal cell body
  • nucleolus
  • perinuclear region of cytoplasm
  • nucleus
  • gemini of coiled bodies
Biological process
  • cell differentiation
  • axon development
  • pre-mRNA catabolic process
  • Cajal body organization
  • mRNA processing
  • apoptotic process involved in development
  • positive regulation of growth
  • inner cell mass cell proliferation
  • cellular response to epidermal growth factor stimulus
  • positive regulation of gene expression
  • regulation of myelination
  • positive regulation of transcription involved in G1/S transition of mitotic cell cycle
  • RNA splicing
  • spinal cord development
  • positive regulation of RNA splicing
  • positive regulation of protein import into nucleus
  • cell population proliferation
  • DNA endoreduplication
  • microtubule cytoskeleton organization
  • trophectodermal cell proliferation
  • signal transduction
  • negative regulation of motor neuron apoptotic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8882

22687

Ensembl

ENSG00000109917

ENSMUSG00000032078

UniProt

O75312

Q62384

RefSeq (mRNA)

NM_003904
NM_001317086

NM_011752

RefSeq (protein)

NP_001304015
NP_003895

NP_035882

Location (UCSC)Chr 11: 116.77 – 116.79 MbChr 9: 46.18 – 46.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein ZPR1 is a protein that in humans is encoded by the ZNF259 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109917 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032078 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Galcheva-Gargova Z, Konstantinov KN, Wu IH, Klier FG, Barrett T, Davis RJ (June 1996). "Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor". Science. 272 (5269): 1797–802. Bibcode:1996Sci...272.1797G. doi:10.1126/science.272.5269.1797. PMID 8650580. S2CID 6851783.
  6. ^ Galcheva-Gargova Z, Gangwani L, Konstantinov KN, Mikrut M, Theroux SJ, Enoch T, Davis RJ (October 1998). "The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells". Molecular Biology of the Cell. 9 (10): 2963–71. doi:10.1091/mbc.9.10.2963. PMC 25573. PMID 9763455.
  7. ^ "Entrez Gene: ZNF259 zinc finger protein 259".

Further reading

  • Gangwani L, Mikrut M, Galcheva-Gargova Z, Davis RJ (December 1998). "Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells". The Journal of Cell Biology. 143 (6): 1471–84. doi:10.1083/jcb.143.6.1471. PMC 2132977. PMID 9852145.
  • Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W (September 2000). "Vav family proteins couple to diverse cell surface receptors". Molecular and Cellular Biology. 20 (17): 6364–73. doi:10.1128/MCB.20.17.6364-6373.2000. PMC 86111. PMID 10938113.
  • Narayanan U, Ospina JK, Frey MR, Hebert MD, Matera AG (July 2002). "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta". Human Molecular Genetics. 11 (15): 1785–95. doi:10.1093/hmg/11.15.1785. PMC 1630493. PMID 12095920.
  • Gangwani L, Flavell RA, Davis RJ (April 2005). "ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies". Molecular and Cellular Biology. 25 (7): 2744–56. doi:10.1128/MCB.25.7.2744-2756.2005. PMC 1061650. PMID 15767679.
  • Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (December 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
  • Gangwani L (December 2006). "Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression". The Journal of Biological Chemistry. 281 (52): 40330–40. doi:10.1074/jbc.M608165200. PMID 17068332.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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