Core binding factor
Type of transcription factor
The Core binding factor (CBF) is a group of heterodimeric transcription factors.
Core binding factors are composed of:
- a non-DNA-binding CBFβ chain (CBFB)
- a DNA-binding CBFα chain (RUNX1, RUNX2, RUNX3)
References
- de Bruijn M, Speck N (2004). "Core-binding factors in hematopoiesis and immune function". Oncogene. 23 (24): 4238–48. doi:10.1038/sj.onc.1207763. PMID 15156179.
See also
- AI-10-49, an anti-leukemic drug under development.
External links
- Core+Binding+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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Transcription factors and intracellular receptors
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(2) Zinc finger DNA-binding domains | |||||||||||||||||||||||||||
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(3) Helix-turn-helix domains | |||||||||||||||||||||
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(4) β-Scaffold factors with minor groove contacts | |||||||||||||||||||
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(0) Other transcription factors | |||||||||
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see also transcription factor/coregulator deficiencies
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