MNX1

Protein-coding gene in the species Homo sapiens
MNX1
Identifiers
AliasesMNX1, HB9, HLXB9, HOXHB9, SCRA1, motor neuron and pancreas homeobox 1
External IDsOMIM: 142994; MGI: 109160; HomoloGene: 21137; GeneCards: MNX1; OMA:MNX1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for MNX1
Genomic location for MNX1
Band7q36.3Start156,994,051 bp[1]
End157,010,663 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for MNX1
Genomic location for MNX1
Band5|5 B1Start29,678,032 bp[2]
End29,683,468 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • gonad

  • mucosa of transverse colon

  • testicle

  • beta cell

  • mucosa of sigmoid colon

  • duodenum

  • jejunal mucosa

  • rectum

  • mucosa of ileum
Top expressed in
  • lumbar subsegment of spinal cord

  • islet of Langerhans

  • female urethra

  • embryo

  • endoderm

  • notochord

  • embryonic organizer

  • tail of embryo

  • pharynx

  • neural tube
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • sequence-specific DNA binding
  • DNA-binding transcription factor activity
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleolus
  • nucleus
  • cytosol
Biological process
  • regulation of transcription by RNA polymerase II
  • humoral immune response
  • neuron projection morphogenesis
  • spinal cord motor neuron cell fate specification
  • transcription, DNA-templated
  • anatomical structure morphogenesis
  • endocrine pancreas development
  • regulation of transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3110

15285

Ensembl

ENSG00000130675

ENSMUSG00000001566

UniProt

P50219

A2RSX2

RefSeq (mRNA)

NM_005515
NM_001165255

NM_019944

RefSeq (protein)

NP_001158727
NP_005506

NP_064328

Location (UCSC)Chr 7: 156.99 – 157.01 MbChr 5: 29.68 – 29.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Motor neuron and pancreas homeobox 1 (MNX1), also known as Homeobox HB9 (HLXB9), is a human protein encoded by the MNX1 gene.[5]

Clinical significance

Mutations in the MNX1 gene are associated with Currarino syndrome.[6] Upregulated expression of MNX1-AS1 long noncoding RNA predicts poor prognosis in gastric cancer.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130675 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001566 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HLXB9 homeobox HB9".
  6. ^ Merello E, De Marco P, Ravegnani M, Riccipetitoni G, Cama A, Capra V (2013). "Novel MNX1 mutations and clinical analysis of familial and sporadic Currarino cases". Eur J Med Genet. 56 (12): 648–54. doi:10.1016/j.ejmg.2013.09.011. PMID 24095820.
  7. ^ Zhang, W., Huang, L., Lu, X., Wang, K., Ning, X., & Liu, Z. (2019). Upregulated expression of MNX1-AS1 long noncoding RNA predicts poor prognosis in gastric cancer. Bosnian journal of basic medical sciences, 19(2), 164–171. https://doi.org/10.17305/bjbms.2019.3713

Further reading

  • Catala M (2002). "Genetic control of caudal development". Clin. Genet. 61 (2): 89–96. doi:10.1034/j.1399-0004.2002.610202.x. PMID 11940082. S2CID 45421241.
  • Deguchi Y, Kehrl JH (1991). "Nucleotide sequence of a novel diverged human homeobox gene encodes a DNA binding protein". Nucleic Acids Res. 19 (13): 3742. doi:10.1093/nar/19.13.3742. PMC 328407. PMID 1677181.
  • Deguchi Y, Kehrl JH (1991). "Selective expression of two homeobox genes in CD34-positive cells from human bone marrow". Blood. 78 (2): 323–8. doi:10.1182/blood.V78.2.323.323. PMID 1712647.
  • Lynch SA, Bond PM, Copp AJ, Kirwan WO, Nour S, Balling R, Mariman E, Burn J, Strachan T (1995). "A gene for autosomal dominant sacral agenesis maps to the holoprosencephaly region at 7q36". Nat. Genet. 11 (1): 93–5. doi:10.1038/ng0995-93. hdl:2066/21661. PMID 7550324. S2CID 21202053.
  • Harrison KA, Druey KM, Deguchi Y, Tuscano JM, Kehrl JH (1994). "A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues". J. Biol. Chem. 269 (31): 19968–75. doi:10.1016/S0021-9258(17)32115-4. PMID 7914194.
  • Ross AJ, Ruiz-Perez V, Wang Y, Hagan DM, Scherer S, Lynch SA, Lindsay S, Custard E, Belloni E, Wilson DI, Wadey R, Goodman F, Orstavik KH, Monclair T, Robson S, Reardon W, Burn J, Scambler P, Strachan T (1998). "A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis". Nat. Genet. 20 (4): 358–61. doi:10.1038/3828. PMID 9843207. S2CID 31062371.
  • Heus HC, Hing A, van Baren MJ, Joosse M, Breedveld GJ, Wang JC, Burgess A, Donnis-Keller H, Berglund C, Zguricas J, Scherer SW, Rommens JM, Oostra BA, Heutink P (1999). "A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36". Genomics. 57 (3): 342–51. doi:10.1006/geno.1999.5796. PMID 10329000.
  • Belloni E, Martucciello G, Verderio D, Ponti E, Seri M, Jasonni V, Torre M, Ferrari M, Tsui LC, Scherer SW (2000). "Involvement of the HLXB9 homeobox gene in Currarino syndrome". Am. J. Hum. Genet. 66 (1): 312–9. doi:10.1086/302723. PMC 1288336. PMID 10631160.
  • Hagan DM, Ross AJ, Strachan T, Lynch SA, Ruiz-Perez V, Wang YM, Scambler P, Custard E, Reardon W, Hassan S, Nixon P, Papapetrou C, Winter RM, Edwards Y, Morrison K, Barrow M, Cordier-Alex MP, Correia P, Galvin-Parton PA, Gaskill S, Gaskin KJ, Garcia-Minaur S, Gereige R, Hayward R, Homfray T (2000). "Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene". Am. J. Hum. Genet. 66 (5): 1504–15. doi:10.1086/302899. PMC 1378009. PMID 10749657.
  • Köchling J, Karbasiyan M, Reis A (2001). "Spectrum of mutations and genotype-phenotype analysis in Currarino syndrome". Eur. J. Hum. Genet. 9 (8): 599–605. doi:10.1038/sj.ejhg.5200683. PMID 11528505.
  • Nagel S, Scherr M, Quentmeier H, Kaufmann M, Zaborski M, Drexler HG, MacLeod RA (2005). "HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3". Leukemia. 19 (5): 841–6. doi:10.1038/sj.leu.2403716. PMID 15772702.
  • Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
  • Hori Y, Gu X, Xie X, Kim SK (2005). "Differentiation of insulin-producing cells from human neural progenitor cells". PLOS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMC 1087208. PMID 15839736.
  • Kapranov P, Drenkow J, Cheng J, Long J, Helt G, Dike S, Gingeras TR (2005). "Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays". Genome Res. 15 (7): 987–97. doi:10.1101/gr.3455305. PMC 1172043. PMID 15998911.
  • von Bergh AR, van Drunen E, van Wering ER, van Zutven LJ, Hainmann I, Lönnerholm G, Meijerink JP, Pieters R, Beverloo HB (2006). "High incidence of t(7;12)(q36;p13) in infant AML but not in infant ALL, with a dismal outcome and ectopic expression of HLXB9". Genes Chromosomes Cancer. 45 (8): 731–9. doi:10.1002/gcc.20335. PMID 16646086. S2CID 27381746.
  • Kim IS, Oh SY, Choi SJ, Kim JH, Park KH, Park HK, Kim JW, Ki CS (2007). "Clinical and genetic analysis of HLXB9 gene in Korean patients with Currarino syndrome". J. Hum. Genet. 52 (8): 698–701. doi:10.1007/s10038-007-0173-y. PMID 17612791.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


Stub icon

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e