HES5 |
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Identifiers |
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Aliases | HES5, bHLHb38, hes family bHLH transcription factor 5 |
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External IDs | OMIM: 607348; MGI: 104876; HomoloGene: 7755; GeneCards: HES5; OMA:HES5 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 1 (human)[1] |
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| Band | 1p36.32 | Start | 2,528,745 bp[1] |
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End | 2,530,263 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 4 (mouse)[2] |
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| Band | 4 E2|4 86.01 cM | Start | 155,045,380 bp[2] |
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End | 155,046,828 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gonad
- ventricular zone
- ganglionic eminence
- nucleus accumbens
- amygdala
- hypothalamus
- apex of heart
- anterior cingulate cortex
- caudate nucleus
- putamen
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| Top expressed in | - medial ganglionic eminence
- Rostral migratory stream
- ventricular zone
- somite
- neural tube
- substantia nigra
- thin ascending limb of loop of Henle
- supraoptic nucleus
- olfactory bulb
- lateral septal nucleus
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - DNA binding
- protein dimerization activity
- transcription factor binding
- chromatin binding
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- double-stranded DNA binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- transcription corepressor activity
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
| Cellular component | - nucleoplasm
- nucleus
- cellular component
| Biological process | - Notch signaling pathway
- auditory receptor cell fate determination
- establishment of epithelial cell polarity
- cell differentiation
- negative regulation of astrocyte differentiation
- regulation of inner ear auditory receptor cell differentiation
- regulation of transcription, DNA-templated
- negative regulation of neuron differentiation
- inner ear receptor cell stereocilium organization
- comma-shaped body morphogenesis
- metanephric nephron tubule morphogenesis
- chondrocyte differentiation
- central nervous system myelination
- negative regulation of transcription by RNA polymerase II
- cell maturation
- negative regulation of forebrain neuron differentiation
- transcription, DNA-templated
- nervous system development
- negative regulation of stem cell differentiation
- neuronal stem cell population maintenance
- positive regulation of transcription, DNA-templated
- multicellular organism development
- glial cell fate commitment
- telencephalon development
- brain development
- inner ear auditory receptor cell differentiation
- cell adhesion
- astrocyte differentiation
- cartilage development
- forebrain radial glial cell differentiation
- regulation of myelination
- negative regulation of oligodendrocyte differentiation
- S-shaped body morphogenesis
- neural tube development
- neuron differentiation
- positive regulation of cell population proliferation
- positive regulation of BMP signaling pathway
- negative regulation of pro-B cell differentiation
- regulation of cell differentiation
- smoothened signaling pathway
- oligodendrocyte development
- camera-type eye development
- specification of loop of Henle identity
- regulation of epithelial cell proliferation
- negative regulation of transcription, DNA-templated
- negative regulation of inner ear receptor cell differentiation
- regulation of neurogenesis
- positive regulation of receptor signaling pathway via JAK-STAT
- positive regulation of Notch signaling pathway
- positive regulation of transcription by RNA polymerase II
- positive regulation of smooth muscle cell proliferation
- positive regulation of tyrosine phosphorylation of STAT protein
- protein-containing complex assembly
- somitogenesis
- central nervous system development
- anterior/posterior pattern specification
- negative regulation of inner ear auditory receptor cell differentiation
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000273529 ENSG00000197921 |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 2.53 – 2.53 Mb | Chr 4: 155.05 – 155.05 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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