Protein-coding gene in the species Homo sapiens
FOXF1 |
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Identifiers |
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Aliases | FOXF1, ACDMPV, FKHL5, FREAC1, forkhead box F1 |
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External IDs | OMIM: 601089; MGI: 1347470; HomoloGene: 1114; GeneCards: FOXF1; OMA:FOXF1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 16 (human)[1] |
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| Band | 16q24.1 | Start | 86,510,527 bp[1] |
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End | 86,515,422 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 8 (mouse)[2] |
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| Band | 8 E1|8 70.31 cM | Start | 121,811,125 bp[2] |
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End | 121,814,883 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - muscle layer of sigmoid colon
- gastric mucosa
- right lung
- lower lobe of lung
- urinary bladder
- mucosa of urinary bladder
- buccal mucosa cell
- upper lobe of lung
- upper lobe of left lung
- pylorus
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| Top expressed in | - right lung lobe
- left lung lobe
- migratory enteric neural crest cell
- molar
- somatopleuric mesenchyme
- lamina propria of urethra
- mandibular prominence
- urinary bladder
- extraembryonic membrane
- yolk sac
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- DNA-binding transcription factor activity
- DNA-binding transcription activator activity, RNA polymerase II-specific
- transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Cellular component | - transcription regulator complex
- nucleus
| Biological process | - somitogenesis
- regulation of smooth muscle cell differentiation
- renal system development
- ureter development
- regulation of transcription, DNA-templated
- lung morphogenesis
- embryonic foregut morphogenesis
- lung development
- positive regulation of cell migration
- endocardial cushion development
- cellular response to organic cyclic compound
- extracellular matrix organization
- cardiac left ventricle morphogenesis
- in utero embryonic development
- negative regulation of transcription by RNA polymerase II
- negative regulation of mast cell degranulation
- smooth muscle cell differentiation
- morphogenesis of a branching structure
- venous blood vessel development
- cellular response to cytokine stimulus
- right lung morphogenesis
- transcription, DNA-templated
- vasculogenesis
- positive regulation of transcription, DNA-templated
- respiratory tube development
- heart development
- determination of left/right symmetry
- establishment of epithelial cell apical/basal polarity
- blood vessel development
- embryonic ectodermal digestive tract morphogenesis
- positive regulation of mesenchymal cell proliferation
- embryonic digestive tract morphogenesis
- animal organ morphogenesis
- pancreas development
- detection of wounding
- mesenchyme migration
- smoothened signaling pathway
- lateral mesodermal cell differentiation
- lung alveolus development
- digestive tract development
- lung vasculature development
- mesoderm development
- epithelial tube branching involved in lung morphogenesis
- negative regulation of inflammatory response
- lung lobe morphogenesis
- ductus arteriosus closure
- embryonic digestive tract development
- positive regulation of transcription by RNA polymerase II
- epithelial cell differentiation involved in mammary gland alveolus development
- midgut development
- positive regulation of cell-substrate adhesion
- transcription by RNA polymerase II
- cell differentiation
- cell-cell adhesion
- trachea development
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 16: 86.51 – 86.52 Mb | Chr 8: 121.81 – 121.81 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Forkhead box protein F1 (FOXF1) is a protein that in humans is encoded by the FOXF1 gene.[5][6][7]
Function
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. FOX1 protein is important in the development of the pulmonary mesenchyme and the development of the gastrointestinal tract.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000103241 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042812 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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- ^ Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (Oct 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.
- ^ "Entrez Gene: FOXF1 forkhead box F1".
- ^ "FOXF1 gene: MedlinePlus Genetics". medlineplus.gov. Retrieved 2021-06-10.
Further reading
- Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W, Thies U (Jun 1994). "Human brain factor 1, a new member of the fork head gene family". Genomics. 21 (3): 551–7. doi:10.1006/geno.1994.1313. PMID 7959731.
- Hellqvist M, Mahlapuu M, Samuelsson L, Enerbäck S, Carlsson P (Feb 1996). "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2". The Journal of Biological Chemistry. 271 (8): 4482–90. doi:10.1074/jbc.271.8.4482. PMID 8626802.
- Hellqvist M, Mahlapuu M, Blixt A, Enerbäck S, Carlsson P (Sep 1998). "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB". The Journal of Biological Chemistry. 273 (36): 23335–43. doi:10.1074/jbc.273.36.23335. PMID 9722567.
- Mahlapuu M, Pelto-Huikko M, Aitola M, Enerbäck S, Carlsson P (Oct 1998). "FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces". Developmental Biology. 202 (2): 183–95. doi:10.1006/dbio.1998.9010. PMID 9769171.
- Coon DR, Roberts DJ, Loscertales M, Kradin R (Apr 2006). "Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia". Experimental and Molecular Pathology. 80 (2): 119–23. doi:10.1016/j.yexmp.2005.12.003. PMID 16448649.
- Lomenick JP, Hubert MA, Handwerger S (Nov 2006). "Transcription factor FOXF1 regulates growth hormone variant gene expression". American Journal of Physiology. Endocrinology and Metabolism. 291 (5): E947-51. doi:10.1152/ajpendo.00128.2006. PMID 16772323.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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(1) Basic domains |
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(1.1) Basic leucine zipper (bZIP) | |
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(1.2) Basic helix-loop-helix (bHLH) | Group A | |
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Group B | |
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Group C bHLH-PAS | |
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Group D | |
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Group E | |
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Group F bHLH-COE | |
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(1.3) bHLH-ZIP | |
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(1.4) NF-1 | |
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(1.5) RF-X | |
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(1.6) Basic helix-span-helix (bHSH) | |
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(2) Zinc finger DNA-binding domains |
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(2.1) Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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see also transcription factor/coregulator deficiencies |