NKX6-1 |
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Identifiers |
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Aliases | NKX6-1, NKX6.1, NKX6A, NK6 homeobox 1 |
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External IDs | OMIM: 602563; MGI: 1206039; HomoloGene: 4495; GeneCards: NKX6-1; OMA:NKX6-1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 4 (human)[1] |
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| Band | 4q21.23 | Start | 84,491,985 bp[1] |
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End | 84,499,292 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5|5 E4- E5 | Start | 101,806,005 bp[2] |
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End | 101,812,862 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gastric mucosa
- islet of Langerhans
- testicle
- body of pancreas
- stromal cell of endometrium
- left lobe of thyroid gland
- substantia nigra
- left testis
- hypothalamus
- right testis
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| Top expressed in | - islet of Langerhans
- primordial pancreas
- stria vascularis
- embryo
- facial motor nucleus
- esophagus
- spinal cord
- anterior horn of spinal cord
- vestibular membrane of cochlear duct
- cochlea
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - DNA-binding transcription repressor activity, RNA polymerase II-specific
- sequence-specific DNA binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- chromatin binding
- DNA-binding transcription factor activity
- DNA binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Cellular component | - nucleus
- extracellular exosome
| Biological process | - smoothened signaling pathway
- detection of glucose
- pancreas development
- transcription, DNA-templated
- regulation of axon extension
- multicellular organism development
- cellular response to peptide hormone stimulus
- central nervous system neuron differentiation
- response to nicotine
- negative regulation of glial cell differentiation
- type B pancreatic cell proliferation
- cellular response to cytokine stimulus
- positive regulation of DNA-binding transcription factor activity
- neurogenesis
- regulation of transcription by RNA polymerase II
- type B pancreatic cell development
- positive regulation of neuron differentiation
- negative regulation of transcription by RNA polymerase II
- positive regulation of type B pancreatic cell development
- type B pancreatic cell maturation
- oligodendrocyte differentiation
- regulation of transcription, DNA-templated
- cell population proliferation
- positive regulation of transcription by RNA polymerase II
- transcription by RNA polymerase II
- positive regulation of glial cell differentiation
- cell differentiation
- positive regulation of insulin secretion
- animal organ morphogenesis
- regulation of neuron migration
- neuron migration
- regulation of insulin secretion
- endocrine pancreas development
- type B pancreatic cell differentiation
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 4: 84.49 – 84.5 Mb | Chr 5: 101.81 – 101.81 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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