SIX2 |
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Identifiers |
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Aliases | SIX2, SIX homeobox 2 |
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External IDs | OMIM: 604994; MGI: 102778; HomoloGene: 56518; GeneCards: SIX2; OMA:SIX2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 2 (human)[1] |
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| Band | 2p21 | Start | 45,005,182 bp[1] |
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End | 45,009,452 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 17 (mouse)[2] |
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| Band | 17 E4|17 55.72 cM | Start | 85,991,705 bp[2] |
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End | 85,995,702 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - olfactory zone of nasal mucosa
- gastrocnemius muscle
- parotid gland
- muscle of thigh
- nasal epithelium
- tendon of biceps brachii
- testicle
- tibialis anterior muscle
- palpebral conjunctiva
- pituitary gland
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| Top expressed in | - genital tubercle
- vestibular membrane of cochlear duct
- maxillary prominence
- parotid gland
- external carotid artery
- vestibular sensory epithelium
- internal carotid artery
- urethra
- utricle
- muscle of thigh
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - DNA binding
- sequence-specific DNA binding
- DNA-binding transcription factor activity
- DNA-binding transcription activator activity, RNA polymerase II-specific
- transcription factor binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- protein-containing complex binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- transcription cis-regulatory region binding
| Cellular component | - nucleus
- transcription regulator complex
| Biological process | - embryonic skeletal system morphogenesis
- regulation of chondrocyte differentiation
- regulation of transcription, DNA-templated
- positive regulation of chondrocyte proliferation
- chondrocyte differentiation
- protein import into nucleus
- kidney development
- negative regulation of cell differentiation
- anatomical structure morphogenesis
- mesenchymal stem cell maintenance involved in nephron morphogenesis
- mesenchymal to epithelial transition involved in metanephros morphogenesis
- mesenchymal cell differentiation involved in kidney development
- mesenchymal stem cell proliferation
- transcription by RNA polymerase II
- regulation of branching involved in ureteric bud morphogenesis
- multicellular organism development
- nephron morphogenesis
- nephron development
- middle ear morphogenesis
- embryonic digestive tract morphogenesis
- embryonic cranial skeleton morphogenesis
- regulation of ossification
- cell population proliferation
- mesodermal cell fate specification
- anterior/posterior axis specification
- metanephros development
- cell migration
- positive regulation of transcription by RNA polymerase II
- condensed mesenchymal cell proliferation
- negative regulation of transcription, DNA-templated
- anatomical structure development
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 2: 45.01 – 45.01 Mb | Chr 17: 85.99 – 86 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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