Group of proteins
Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence.[1] Their DNA-binding domain is a POU domain.
There are eight Octamer proteins in humans (Oct1–11),[2] which have been renamed according to the different classes of POU domain.[3] Octamer-3/4, also known as POU5F1, is one of the Yamanaka factors, which are critical for the maintenance and self-renewal of embryonic stem cells.[3] On the other hand, Oct-1 and Oct-2 are widely expressed in adult tissues.[3] Oct-7, 8 and 9, also known as "brain factors", are predominantly expressed in the central nervous system during embryonic development.[3] Oct-6 expression is confined to embryonic stem cells and the developing nervous system and skin, while Oct-11 is also involved in skin differentiation.[3]
Human Oct proteins
- Oct-1 - POU2F1
- Oct-2 - POU2F2
- Oct-3/4 – POU5F1
- Oct-6 – POU3F1
- Oct-7 – POU3F2
- Oct-8 – POU3F3
- Oct-9 – POU3F4
- Oct-11 – POU2F3
References
- ^ Petryniak B, Staudt LM, Postema CE, McCormack WT, Thompson CB (1990). "Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 1099–103. Bibcode:1990PNAS...87.1099P. doi:10.1073/pnas.87.3.1099. PMC 53418. PMID 1967834.
- ^ Oct-5 and Oct-10 are not found in humans, while Oct-3 and Oct-4 were identified as the same protein.
- ^ a b c d e Zhao, FQ (1 June 2013). "Octamer-binding transcription factors: genomics and functions". Frontiers in Bioscience (Landmark Edition). 18 (3): 1051–71. doi:10.2741/4162. PMC 4349413. PMID 23747866.
External links
(1) Basic domains |
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(1.1) Basic leucine zipper (bZIP) | |
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(1.2) Basic helix-loop-helix (bHLH) | Group A | |
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Group B | |
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Group C bHLH-PAS | |
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Group D | |
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Group E | |
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Group F bHLH-COE | |
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(1.3) bHLH-ZIP | |
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(1.4) NF-1 | |
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(1.5) RF-X | |
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(1.6) Basic helix-span-helix (bHSH) | |
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(2) Zinc finger DNA-binding domains |
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(2.1) Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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see also transcription factor/coregulator deficiencies |